EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy
EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy
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DOI：
10.1016/j.eplepsyres.2011.04.011
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发表时间：
2011-09-01
影响因子：
2.2
通讯作者：
Fekete, I.
中科院分区：
文献类型：
--
作者：
Clemens, B.;Puskas, S.;Fekete, I.
目的：在这项探索性研究中，对未经治疗的特发性全身性癫痫 (IGE) 患者的半球内皮质-皮质脑电图功能连接 (fC) 进行了调查。患者和方法：在 19 名初治 IGE 患者和 19 名匹配的健康人之间进行了分组比较。将 90 x 2 s 的 19 个通道的清醒、发作间期背景 EEG 信号（无癫痫样电位）处理至 LORETA（低分辨率电磁断层扫描）软件，以计算 2394 个体素的电流源密度，这些体素代表大脑皮层的 25 个非常窄的 1 Hz 带宽 (VNB) 频带（从 1 到 25 Hz）。 EEG fC 在已经本地化的来源中进行了调查。分别计算左半球和右半球内 33 个感兴趣区域 (ROI) 的皮尔逊相关系数 (R)。通过t统计计算组间差异。校正后的 p < 0.05 差异被认为具有统计显着性。主要结果： (1) fC 差异的解剖模式显示出很大的频率依赖性。 (2) 大多数 VNB 中半球不对称性很突出。 (3) 与包含 >6 Hz 频率下 fC 增加和减少的混合模式相比，IGE 组中所有 VNB 在 1-6 Hz 频率范围内发现 fC 减少。 (4)在5-25 Hz范围内，皮质前部的fC降低为主，后部的fC升高为主。 (5) 结果描绘了前网络和后网络。讨论：(1) 1-6 Hz 频带内的 fC 降低可能表明与尚未隐藏的结构网络异常存在某种关系。 (2) fC 的解剖模式表明发作间期状态下频率依赖的病理性耦合和解耦过程。 (3)这两个网络可能有助于了解IGE患者的癫痫发作倾向和癫痫发作沉淀。意义：这是第一个探讨IGE患者发作间期脑电图fC的研究。论证了 EEG 频率在 IGE 中评估 fC 的重要性，并给出了进一步研究的起点。 (C) 2011 Elsevier B.V. 保留所有权利。
Aims: Intrahemispheric, cortico-cortical EEG functional connectivity (fC) was investigated in untreated patients with idiopathic generalized epilepsy (IGE) in this explorative study.Patients and methods: Group comparison was carried out between 19, drug-naive IGE patients and 19, matched healthy persons. 90 x 2 s of 19 channels waking, interictal background EEG signal (without epileptiform potentials) were processed to the LORETA (low resolution electromagnetic tomography) software to compute current source density for 2394 voxels representing parcels of the cerebral cortex for 25 very narrow bands of 1 Hz bandwidth (VNBs) from 1 to 25 Hz. EEG fC was investigated among the already localized sources. Pearson correlation coefficients (R) were computed among the 33 regions of interest (ROI) within the left and within the right hemisphere, separately. Group differences were computed by means of t-statistics. Corrected p < 0.05 differences were accepted as statistically significant.Main results: (1) The anatomical patterns of the fC differences showed great frequency-dependency. (2) Hemispheric asymmetry was prominent within most VNBs. (3) Decreased fC in the IGE group was found across all VNBs in the 1-6 Hz frequency range as compared to mixed patterns comprising both increased and decreased fC at >6 Hz frequencies. (4) In the 5-25 Hz range, decreased fC dominated in the anterior, increased fC in the posterior parts of the cortex. (5) The results delineated an anterior and a posterior network.Discussion: (1) Decreased fC in the 1-6 Hz band might indicate some relationship to yet hidden structure network abnormalities. (2) The anatomical patterns of fC indicate frequency-dependent, pathological coupling and decoupling processes in the interictal state. (3) The two networks might help to understand seizure liability and seizure precipitation in IGE.Significance: This is the first study to explore EEG fC in the interictal condition of IGE patients. The importance of EEG frequencies in evaluating fC in IGE was demonstrated and starting points for further research were given. (C) 2011 Elsevier B.V. All rights reserved.