Pressure-Volume Relationship of a Pulsatile Blood Pump for Ventricular Assist Device Development
Pressure-Volume Relationship of a Pulsatile Blood Pump for Ventricular Assist Device Development
复制标题
用于心室辅助装置开发的脉动血泵的压力-容积关系
DOI：
10.1097/00002480-200105000-00027
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发表时间：
2001
期刊：
影响因子：
4.2
通讯作者：
J. Antaki
中科院分区：
文献类型：
--
作者：
Yih;J. Boston;M. Simaan;P. Miller;J. Antaki
开发了描述 Novacor 左心室辅助系统 (LVAS) 压力-容积关系的数学模型。该模型由集总电阻、电容和电感元件以及一个随时间变化的电容器组成，可使用泵容积测量来估计泵的循环压力生成。泵循环的喷射和填充部分通过两个独立的函数进行建模。通过最小二乘拟合实验室获得的实验数据来估计相应的模型参数。从模型获得的压力和容量波形与从实验室测试和患者获得的数据进行了比较。它在模拟整个循环中泵的运行方面表现良好。该模型可用于评估 LVAS 性能、在线估计 LVAS 患者的心血管参数、泵控制器开发以及作为工程师培训工具。
A mathematical model describing the pressure-volume relationship of the Novacor left ventricular assist system (LVAS) was developed. The model consists of lumped resistance, capacitance, and inductance elements with one time varying capacitor to estimate the cyclic pressure generation of the pump using pump volume measurement. The ejection and filling portions of the pump cycle were modeled with two separate functions. The corresponding model parameters were estimated by least squares fit to experimental data obtained in the laboratory. Pressure and volume waveforms obtained from the model were compared with data obtained from laboratory tests and from patients. It performed well in simulating pump operation throughout the entire cycle. This model can be used for the evaluation of LVAS performance, for on-line estimation of an LVAS patient’s cardiovascular parameters, for pump controller development, and as a tool for engineer training.