Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart review.
Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart review.
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奥卡西平治疗难治性双相情感障碍：回顾性图表回顾。
DOI：
10.1034/j.1399-5618.2002.40104.x
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发表时间：
2002
影响因子：
5.4
通讯作者：
Katzow,JacobJ
中科院分区：
文献类型：
--
作者：
Ghaemi,SNassir;Ko,JamesY;Katzow,JacobJ
目的确定奥卡西平在自然环境下治疗难治性双相情感障碍是否有效。方法对所有接受奥卡西平治疗的门诊患者 (n=13) 的图表进行审查，并使用临床总体改善印象 (CGI-I) 评级量表回顾性评估临床反应。所有患者之前至少使用一种情绪稳定剂治疗均失败。结果 46% (n=6) 的患者出现轻度改善，16% (n=2) 的患者出现中度改善。总样本中的 54% (n=7) 由于不良反应而停止治疗。 结论 在这个难治性、大多为抑郁型双相情感障碍样本中，奥卡西平可能具有轻度至中度的情绪稳定特性。这种自然主义研究因其不受控制的性质而受到限制。
ObjectiveTo determine if oxcarbazepine is effective as treatment for refractory bipolar illness in a naturalistic setting.MethodsAll charts of out‐patients treated with oxcarbazepine (n=13) were reviewed and clinical response assessed retrospectively using the Clinical Global Impression of Improvement (CGI‐I) rating scale. All patients had failed treatment with at least one previous mood stabilizer.ResultsMild improvement was seen in 46% (n=6) and moderate improvement in 16% (n=2). Fifty‐four percent (n=7) of the total sample discontinued treatment because of adverse effects.ConclusionOxcarbazepine may possess mild to moderate mood‐stabilizing properties in this refractory, mostly depressed, bipolar sample. This naturalistic study is limited by its uncontrolled nature.