Dynamic Nano-Interfaces Enable Harvesting of Functional 3D-Engineered Tissues
Dynamic Nano-Interfaces Enable Harvesting of Functional 3D-Engineered Tissues
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DOI：
10.1002/adhm.201500065
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发表时间：
2015-06-03
影响因子：
10
通讯作者：
Akashi, Mitsuru
中科院分区：
文献类型：
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作者：
Nishiguchi, Akihiro;Matsusaki, Michiya;Akashi, Mitsuru
使用具有动态纳米界面的刺激响应性水凝胶膜，成功地从基底收获功能性3D工程组织。界面处的动态润湿性控制允许细胞分离，从而导致组织采集而没有严重损伤和残留聚合物。这种方法可以应用于各种类型的器官，并用于再生医学中的组织移植。
Functional 3D-engineered tissues are successfully harvested from a substrate using stimuli-responsive hydrogel films with dynamic nano-interface. The dynamic wettability control at the interfaces allows cellular detachment, leading to tissue harvesting without serious damage and remaining polymers. This method can be applied to various types of organs and used for tissue transplantation in regenerative medicine.