Growth of children at high risk of obesity during the first 6 y of life: implications for prevention
Growth of children at high risk of obesity during the first 6 y of life: implications for prevention
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DOI：
10.1093/ajcn/81.1.140
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发表时间：
2005-01-01
影响因子：
7.1
通讯作者：
Stunkard, AJ
中科院分区：
文献类型：
--
作者：
Berkowitz, RI;Stallings, VA;Stunkard, AJ
背景：家庭因素对儿童肥胖的影响还知之甚少。目的：目的是评估超重或消瘦母亲所生儿童在出生后6年内的生长差异。设计：根据母亲的超重[体重指数]，对33名肥胖高危儿童和37名肥胖低危儿童的身体大小和组成进行研究在费城儿童医院，从3个月到6岁，反复测量了两组患者的体重指数（BMI;单位：kg /m2），分别为30.2 +/- 4.2和19.5 +/- 1.1。到第4年，高风险儿童的体重、BMI和瘦体重大于低风险儿童。到第6年，高风险儿童的体重甚至比低风险儿童的体重更大（23.4 +/- 6.4对比20.4 +/- 2.1 kg; P < 0.02），并且，高风险儿童的脂肪量首次大于低风险儿童（6.7 +/- 5.7对比3.8 +/- 1.2 kg; P < 0.02）。33名高危儿童中有10名在第6年超过BMI的第85百分位数，而37名低危儿童中有1名超过BMI的第85百分位数（比值比= 15.7）。加速体重增加预测高风险组的地位，更大的重量在第2年，和较低的家庭income.Conclusion：人体测量的措施是没有显着差异组之间在第2年，体重和瘦体重更大，在第4年和第6年，脂肪量更大，在第6年的高风险儿童。
Background: The contribution of familial factors to adiposity in children is poorly understood. Objective: The objective was to assess differences in growth in the first 6 y of life in children born to either overweight or lean mothers.Design: The body size and composition of 33 children at high risk and 37 children at low risk of obesity on the basis of the mother's overweight [body mass index (BMI; in kg /m(2)) of 30.2 +/- 4.2 and 19.5 +/- 1.1, respectively] were measured repeatedly from 3 mo to 6 y of age at the Children's Hospital of Philadelphia.Results: At year 2, no significant differences in any measure were observed between the high- and low-risk groups. By year 4, weight, BMI, and lean body mass were greater in the high-risk than in the low-risk children. By year 6, weight was even greater in the high-risk than in the low-risk children (23.4 +/- 6.4 compared with 20.4 +/- 2.1 kg; P < 0.02), and, for the first time, fat mass was greater in the high-risk than in the low-risk children (6.7 +/- 5.7 compared with 3.8 +/- 1.2 kg; P < 0.02). Ten of 33 high-risk children exceeded the 85th percentile of BMI at year 6 compared with I of 37 low-risk children (odds ratio = 15.7). Accelerated weight gain was predicted by high-risk group status, greater weight at year 2, and lower family income.Conclusion: Anthropometric measures were not significantly different between groups at year 2; weight and lean body mass were greater at years 4 and 6, and fat mass was greater at year 6 in high-risk children.