The treatment of painful osseous metastases with phosphorus-32-labeled phosphates.
The treatment of painful osseous metastases with phosphorus-32-labeled phosphates.
复制标题
用磷 32 标记的磷酸盐治疗疼痛性骨转移。
作者：
E. Silberstein
在大约80%的治疗患者中，大范围使用32P正磷酸盐可减少或缓解成骨细胞转移引起的疼痛。该药物的疗效与较新的药物和广域放射治疗的疗效相同，这一点在一篇文献综述中得到了证实，该文献综述报道了在50年期间使用32P正磷酸盐的28个系列。给予32P的活动与接受该活动的疼痛减轻的患者百分比之间没有剂量反应关系。只有一人死于这种放射性药物。
32P orthophosphate administered in a wide range of activity reduces or relieves the pain from osteoblastic metastases in approximately 80% of patients treated. The efficacy of this agent is equal to that of newer agents and of wide field radiotherapy, as documented in a literature review of 28 series reporting the use of 32P orthophosphate over a 50-year period. There is no dose-response relationship between the activity of 32P given and the percentage of patients experiencing pain reduction who received that activity. Only one death has been attributed to this radiopharmaceutical.