Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
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DOI：
10.1111/dote.12023
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发表时间：
2013-01
期刊：
影响因子：
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通讯作者：
C. Zhan;Yu Shi;C. Lu;Qun Wang
中科院分区：
文献类型：
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作者：
C. Zhan;Yu Shi;C. Lu;Qun Wang
丙酮酸激酶M2（PKM 2）和瓦尔堡效应（Warburg effect）通过为大分子生物合成积累更多的原料而在肿瘤的发生发展中起重要作用。然而，PKM2与癌症之间的相关性报道很少。在此，我们研究PKM2在食管鳞状细胞癌（ESCC）中的表达。PKM2在食管鳞癌组织中的表达明显高于正常组织，与食管鳞癌的临床特征和预后密切相关。特别是，我们发现PKM 2的表达与食管鳞癌的分化状态密切相关，并在体外进一步证实了这一发现。因此，我们的数据表明，PKM 2可能是一个有用的指标，以确定与食管鳞癌患者的生存。结合以往对PKM 2、瓦尔堡效应与肿瘤细胞分化之间关系的研究，本研究推测PKM 2和瓦尔堡效应在肿瘤细胞分化中的直接作用，而不仅仅是提供促进肿瘤进展的合成中间体。
It's frequently stated that the pyruvate kinase M2 (PKM2) and Warburg effect are important for cancer development by accumulating more raw materials for macromolecule biosynthesis. However, the correlation between PKM2 and cancer is poorly reported. Here, we investigated the PKM2 expression in esophageal squamous cell cancer (ESCC). We observed that the expression of PKM2 was much higher in ESCC than in control normal tissue, and it is highly associated with many clinical features and prognosis. Specially, we found that the expression of PKM2 was closely related to the differentiation state of ESCC, and we further confirmed this discovery in vitro. As a result, out data indicated that PKM2 might be a useful indicator for determining the survival of patients with ESCC. Considering previous researches on the link among PKM2, Warburg effect, and differentiation, our study inferred the direct roles of PKM2 and Warburg effect in the differentiation of cancer cells rather than only providing synthetic intermediates for the promotion of cancer's progression.