Supplementation of calves with stabilized orthosilicic acid - Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage
Supplementation of calves with stabilized orthosilicic acid - Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage
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DOI：
10.1007/bf02785389
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发表时间：
1997-02-01
影响因子：
3.9
通讯作者：
VandenBerghe, DA
中科院分区：
文献类型：
--
作者：
Calomme, MR;VandenBerghe, DA
在一项双盲、安慰剂对照补充研究中，对保持正常饮食的小牛进行了研究，研究了稳定原硅酸中硅的生物利用度。以稳定原硅酸形式存在的膳食硅总摄入量增加了 4.9%。补充 Si 23 周后，尽管给予低 Si 剂量和充足的 Si 饮食，但与对照动物相比，血清 Si 浓度增加了 70%（p = 0.0001，n = 29）。单独施用的 Si 剂量与血清 Si 浓度显着相关（r = 0.44，p = 0.016，n = 29）。 Si 组真皮中的胶原蛋白浓度显着较高（p = 0.019，n = 4），并且血清中的 Si 浓度与软骨中的胶原蛋白浓度呈正相关（r = 0.72，p = 0.018，n = 9）。与对照动物相比，补充 Si 的动物血清中钙 (Ca) 和磷 (P) 浓度略高。在血清中，Si 和 Ca 浓度之间存在显着的线性关系（r = 0.31，p = 0.019，n = 59），而镁浓度与 Si 浓度略有相关（r = 0.25，p = 0.068，n = 59）。总之，以稳定原硅酸的形式将膳食硅总摄入量增加 4.9%，导致血清中硅浓度提高 70%，表明该补充剂中硅的生物利用度较高。血清Si浓度与软骨中胶原浓度和血清Ca浓度分别呈正相关，表明Si参与外部脱细胞基质成分的形成和Ca代谢。
The bioavailability of silicon in stabilized orthosilicic acid was investigated in a double blind, placebo controlled supplementation study of calves maintained on a normal diet. The total dietary Si intake was increased by 4.9% in the form of stabilized orthosilicic acid. After 23 wk of Si supplementation, the serum Si concentration increased (p = 0.0001, n = 29) by 70% compared to control animals in spite of the low Si dose administered and the Si adequate diet. The individually administered Si dose was significantly associated with the serum Si concentration (r = 0.44, p = 0.016, n = 29). The collagen concentration in dermis was significantly higher (p = 0.019, n = 4) in the Si group and a positive correlation (r = 0.72, p = 0.018, n = 9) was found between the Si concentration in serum and the collagen concentration ill cartilage. The calcium (Ca) and phosphorus (P) concentrations in serum were marginally higher for animals supplemented with Si compared to control animals. In serum, a significant linear relationship was found between the Si and the Ca concentration (r = 0.31, p = 0.019, n = 59), whereas the magnesium concentration correlated marginally with the Si concentration (r = 0.25, p = 0.068, n = 59). In summary, increasing the total dietary Si intake by 4.9% in the form of stabilized orthosilicic acid resulted in a 70% higher Si concentration in serum indicating a high bioavailability of Si in this supplement. The positive correlation between the serum Si concentration and the collagen concentration in cartilage and the serum Ca concentration, respectively, suggest the involvement of Si both in the formation of ext acellular matrix components and in Ca metabolism.