Evaluation of salivary gland fat fraction values in patients with primary Sjogren's syndrome by mDIXON quant imaging: Initial findings
Evaluation of salivary gland fat fraction values in patients with primary Sjogren's syndrome by mDIXON quant imaging: Initial findings
复制标题
通过 mDIXON 定量成像评估原发性干燥综合征患者唾液腺脂肪分数值：初步结果
DOI：
10.1016/j.ejrad.2019.108776
复制
发表时间：
2020-02-01
影响因子：
3.3
通讯作者：
Zhou, Zhengyang
中科院分区：
文献类型：
--
作者：
Chu, Chen;Feng, Qianqian;Zhou, Zhengyang
目的：探讨唾液脂肪分数（FF）值在原发性干燥综合征（pSS）患者评价中的作用。材料与方法：共纳入28例pSS患者、10例疑似pSS患者和28名志愿者。腮腺和颌下腺的FF值由mDIXON Quant生成，采用单因素方差分析比较各组间的FF值。应用受体操作特征分析来评估腮腺和下颌下FF值在区分pSS患者和非pSS患者中的诊断作用。我们特别关注于区分0级pSS患者和疑似pSS患者。结果：pSS患者腮腺和下颌骨的平均FF值明显高于健康志愿者。pSS患者的下颌下平均FF值高于疑似患者。下颌下FF值在区分pSS患者与非pSS患者（曲线下面积[AUC] = 0.927 vs. 0.734）、pSS患者与疑似pSS患者（AUC = 0.907 vs. 0.725）方面优于腮腺FF值。该值在区分0级pSS患者和疑似pSS患者方面也表现更好（AUC = 0.925 vs. 0.783）。结论：唾液腺FF值，尤其是颌下腺FF值，是区分pSS患者与疑似pSS患者及健康志愿者的重要指标。
Purpose: To explore the role of salivary fat fraction (FF) values in evaluating patients with primary Sjogren's syndrome (pSS).Material and method: A total of 28 patients with pSS, ten patients with suspected pSS, and 28 volunteers were enrolled. The FF values of the parotid and submandibular glands were generated from mDIXON Quant. A one-way analysis of variance was used to compare the FF values among the groups. A receiver-operating characteristic analysis was applied to assess the diagnostic performance of the parotid and submandibular FF values in distinguishing patients with pSS from non-pSS subjects. In particular, we focused on distinguishing patients with grade 0 pSS from those with suspected pSS.Results: The parotid and submandibular mean FF value of patients with pSS was significantly higher than that of healthy volunteers. The submandibular mean FF value of patients with pSS was higher than those suspected ones. Submandibular FF value performed better than parotid FF value in differentiating patients with pSS from those non-pSS subjects (area under the curve [AUC] = 0.927 vs. 0.734), patients with pSS from patients with suspected pSS (AUC = 0.907 vs. 0.725). This value also performed better at distinguishing patients with grade 0 pSS from those patients with suspected pSS (AUC = 0.925 vs. 0.783).Conclusions: The salivary gland FF value, especially the submandibular gland FF value, distinguished patients with pSS from those patients with suspected pSS and healthy volunteers.