Understanding the Impact of Uterine Fibroids on Human Endometrium Function.
Understanding the Impact of Uterine Fibroids on Human Endometrium Function.
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DOI：
10.3389/fcell.2021.633180
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发表时间：
2021
影响因子：
5.5
通讯作者：
Al-Hendy A
中科院分区：
文献类型：
--
作者：
Navarro A;Bariani MV;Yang Q;Al-Hendy A
子宫肌瘤（平滑肌瘤）是世界范围内育龄妇女最常见的妇科良性肿瘤。它们会导致大量月经出血，通常会导致严重贫血，骨盆疼痛/压力，不孕症和其他使人虚弱的疾病。纤维瘤被认为是子宫肌层产生的单克隆肿瘤，最近的研究表明，纤维瘤积极影响子宫内膜全球。研究表明，切除肌瘤的数量与生育问题之间存在直接关系。在这篇综述中，我们的目的是提供一个完整的概述子宫肌瘤的起源和分子途径和过程中牵连的发展和增长，这可以直接影响健康的子宫内膜的功能。肌瘤最常见的特征之一是细胞外基质（ECM）成分的过量产生，这有助于肌瘤的僵硬和扩张。ECM可以作为促纤维化生长因子如转化生长因子β（TGF-β）的储存库以及它们的可用性和作用的调节剂。纤维瘤还引起导致子宫壁收缩力降低和子宫肌层刚性增加的机械转导变化，这影响正常的生物子宫功能，如月经出血、容受性和着床。肌瘤和子宫肌层细胞中微小RNA（miRNA）表达的变化似乎调节TGF-β途径和ECM产生的调节因子的表达。总之，这些发现表明ECM组分、TGF-β家族信号传导、miRNA和子宫内膜血管系统之间存在相互作用。靶向这些成分将是开发不仅治疗子宫肌瘤而且恢复正常子宫内膜功能的新药物的基础。
Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women of reproductive age worldwide. They cause heavy menstrual bleeding, usually leading to severe anemia, pelvic pain/pressure, infertility, and other debilitating morbidities. Fibroids are believed to be monoclonal tumors arising from the myometrium, and recent studies have demonstrated that fibroids actively influence the endometrium globally. Studies suggest a direct relationship between the number of fibroids removed and fertility problems. In this review, our objective was to provide a complete overview of the origin of uterine fibroids and the molecular pathways and processes implicated in their development and growth, which can directly affect the function of a healthy endometrium. One of the most common characteristics of fibroids is the excessive production of extracellular matrix (ECM) components, which contributes to the stiffness and expansion of fibroids. ECM may serve as a reservoir of profibrotic growth factors such as the transforming growth factor β (TGF-β) and a modulator of their availability and actions. Fibroids also elicit mechanotransduction changes that result in decreased uterine wall contractility and increased myometrium rigidity, which affect normal biological uterine functions such as menstrual bleeding, receptivity, and implantation. Changes in the microRNA (miRNA) expression in fibroids and myometrial cells appear to modulate the TGF-β pathways and the expression of regulators of ECM production. Taken together, these findings demonstrate an interaction among the ECM components, TGF-β family signaling, miRNAs, and the endometrial vascular system. Targeting these components will be fundamental to developing novel pharmacotherapies that not only treat uterine fibroids but also restore normal endometrial function.
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影响因子：
3.9
作者：
Chuang TD;Panda H;Luo X;Chegini N
通讯作者：
Chegini N
DOI：
10.1196/annals.1335.010
发表时间：
2004-01-01
期刊：
UTERUS AND HUMAN REPRODUCTION
影响因子：
--
作者：
Bulletti, C;De Ziegler, D;Stefanetti, M
通讯作者：
Stefanetti, M
影响因子：
5.8
作者：
Chegini, N;Tang, XM;Ma, CF
通讯作者：
Ma, CF
DOI：
10.1097/med.0000000000000578
发表时间：
2020-12
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Bariani MV;Rangaswamy R;Siblini H;Yang Q;Al-Hendy A;Zota AR
通讯作者：
Zota AR
影响因子：
6.7
作者：
Chuang TD;Rehan A;Khorram O
通讯作者：
Khorram O