Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO 2
Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO 2
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通过含胺药物与 CO 2 反应生成非正统结晶药物盐
DOI：
10.1039/c9cc06429j
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发表时间：
2019
影响因子：
4.9
通讯作者：
Davis, James H.
中科院分区：
文献类型：
--
作者：
Soltani, Mohammad;Mash, Brandon L.;Henseler, Julian;Badri, Sharhzad;Zeller, Matthias;Salter, E. Alan;Wierzbicki, Andrzej;Stenson, Alexandra C.;Davis, James H.
含有胺基的药物与二氧化碳反应形成结晶氨基甲酸铵或氨基甲酸。在这种方法中，盐的阳离子和阴离子，或中性二氧化碳加合物，都来自母体药物，以“掩膜”或前药形式产生新的晶体形式。该方法可作为一种有价值的新工具，用于设计药物的物理性质。
Drugs containing amine groups react with CO2 to form crystalline ammonium carbamates or carbamic acids. In this approach, both the cation and anion of the salt, or the neutral CO2 adduct, are derived from the parent drug, generating new crystalline versions in a ‘masked’ or prodrug form. It is proposed that this approach may serve as a valuable new tool in engineering the physical properties of drugs for formulation purposes.