ELASTIC FREE-ENERGY OF ANISOTROPIC HELICAL RIBBONS AS METASTABLE INTERMEDIATES IN THE CRYSTALLIZATION OF CHOLESTEROL
ELASTIC FREE-ENERGY OF ANISOTROPIC HELICAL RIBBONS AS METASTABLE INTERMEDIATES IN THE CRYSTALLIZATION OF CHOLESTEROL
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DOI：
10.1073/pnas.90.23.11341
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发表时间：
1993-12-01
影响因子：
11.1
通讯作者：
DONOVAN, JM
中科院分区：
文献类型：
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作者：
CHUNG, DS;BENEDEK, GB;DONOVAN, JM
我们报告测量的几何结构和时间演变的亚稳螺旋中间体的途径中的胆固醇结晶在本地和模型胆汁。我们发现胆汁中的卵磷脂成分可以显著影响沿着这一途径的动力学。我们还提出了一个理论描述这些螺旋中间体使用的弹性自由能适合于各向异性双层的倾斜手性两亲物，这提供了一个定量描述所观察到的螺旋带状几何形状和洞察观察到的亚稳态中间体的相对自由能。
We report measurements of the geometrical structure and temporal evolution of metastable helical intermediates in the pathway for cholesterol crystallization in native and model biles. We find that the lecithin component in the bile can dramatically affect the kinetics along this pathway. We also present a theoretical description of these helical intermediates using an elastic free energy appropriate for anisotropic bilayer of tilted chiral amphiphiles, which provides a quantitative description of the observed helical ribbon geometry and insight into the relative free energies of the observed metastable intermediates.