Tissue control of androgen action: The ups and downs of androgen receptor expression
Tissue control of androgen action: The ups and downs of androgen receptor expression
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DOI：
10.1016/j.mce.2017.08.002
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发表时间：
2018-04-15
影响因子：
4.1
通讯作者：
McEwan, Iain J.
中科院分区：
文献类型：
--
作者：
Hunter, Irene;Hay, Colin W.;McEwan, Iain J.
激素睾酮在男性发育和青春期以及整个生命中起着至关重要的作用，作为肌肉和骨骼结构和功能的合成代谢调节剂。睾酮的作用主要通过雄激素受体介导，雄激素受体是核受体超家族的成员。雄激素受体基因位于X染色体上，受体水平在基因转录水平和蛋白质水平上都受到严格控制。Sp1已成为雄激素受体基因表达的主要驱动因素，而雄激素的自动调节以可能的细胞选择性方式与正调节和负调节相关。研究雄激素受体基因的正调控和负调控网络对于了解受体水平的时空控制以及对健康衰老和疾病的影响至关重要。清楚地了解参与调节雄激素受体基因的多种转录因子可能有助于开发和应用激素疗法来增强或抑制受体活性。(C)2017爱思唯尔B.V.保留所有权利。
The hormone testosterone plays crucial roles during male development and puberty and throughout life, as an anabolic regulator of muscle and bone structure and function. The actions of testosterone are mediated, primarily, through the androgen receptor, a member of the nuclear receptor superfamily. The androgen receptor gene is located on the X-chromosome and receptor levels are tightly controlled both at the level of transcription of the gene and post-translationally at the protein level. Sp1 has emerged as the major driver of expression of the androgen receptor gene, while auto-regulation by androgens is associated with both positive and negative regulation in a possible cell-selective manner. Research into the networks of positive and negative regulators of the androgen receptor gene are vital in order to understand the temporal and spatial control of receptor levels and the consequences for healthy aging and disease. A clear understanding of the multiple transcription factors participating in regulation of the androgen receptor gene will likely aid in the development and application of hormone therapies to boast or curb receptor activity. (C) 2017 Elsevier B.V. All rights reserved.