Normalization of triglycerides in type IV hyperlipoproteinemia fails to correct low levels of high-density-lipoprotein cholesterol.
Normalization of triglycerides in type IV hyperlipoproteinemia fails to correct low levels of high-density-lipoprotein cholesterol.
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IV 型高脂蛋白血症中甘油三酯的正常化不能纠正低水平的高密度脂蛋白胆固醇。
DOI：
10.1056/nejm198010163031603
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Schonfeld,G
中科院分区：
文献类型：
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作者：
Witztum,JL;Dillingham,MA;Giese,W;Bateman,J;Diekman,C;Blaufuss,EK;Weidman,S;Schonfeld,G
高密度脂蛋白（HDL）胆固醇可以预防冠心病，人们正在寻找提高低HDL值的方法。横断面人群调查显示，HDL胆固醇与血浆甘油三酯呈负相关，但据我们所知，没有纵向研究表明，降低升高的甘油三酯会提高降低的HDL水平。因此，我们使用饮食疗法来降低29例IV型高脂蛋白血症患者的甘油三酯水平，并评估其对HDL-胆固醇水平的影响。尽管甘油三酯水平从697±90 mg/dl降至333±37 mg/dl（P<0.01），但最初的低HDL-胆固醇值没有改变（29±1 mg/dl至30±1 mg/dl）。即使在12名甘油三酯水平降至正常（从670±99降至170±7，P<0.01）且体重和甘油三酯保持稳定两年的男性亚组中，HDL胆固醇也保持不变（29±1 vs. 32±1）。在甘油三酯正常化的情况下，HDL-胆固醇水平持续较低，这表明HDL胆固醇降低可能是IV型高脂蛋白血症的独立代谢异常。（《新英格兰医学杂志》，1980年; 303：907- 914）
High-density-lipoprotein (HDL) cholesterol protects against coronary heart disease, and ways to raise low HDL values are being sought. Cross-sectional population surveys have shown that HDL cholesterol is inversely related to plasma triglycerides, yet to our knowledge no longitudinal studies have shown that a decrease in elevated triglycerides will raise depressed HDL levels. We therefore used dietary therapy to lower the triglyceride levels of 29 men with Type IV hyperlipoproteinemia and evaluated the effects on HDL-cholesterol levels. Despite a reduction in triglyceride levels from 697±90 to 333±37 mg per deciliter (P<0.01), Initially low HDL-cholesterol values did not change (29±1 to 30±1 mg per deciliter). Even in a subgroup of 12 men whose triglyceride levels fell to normal (from 670±99 to 170±7, P<0.01) and whose weight and triglycerides remained stable for two years, HDL cholesterol remained unchanged (29±1 vs. 32±1). The persistently low HDL-cholesterol level in the presence of normalization of triglycerides suggests that depressed HDL cholesterol may be an independent metabolic abnormality in Type IV hyperlipoproteinemia. (N Engl J Med. 1980; 303:907–14.)