IgA nephropathy and oxidative stress: news on clinically evaluated biomarkers hits the stage
IgA nephropathy and oxidative stress: news on clinically evaluated biomarkers hits the stage
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DOI：
10.1007/s11255-012-0201-5
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发表时间：
2012-08-01
影响因子：
2
通讯作者：
Mertens, Peter R.
中科院分区：
文献类型：
--
作者：
Zhu, Cheng;Mertens, Peter R.
半乳糖缺乏症IgA1 （Gd-IgA1）在IgA肾病（IgAN）的发病机制中起核心作用[1-3]。然而，高水平的循环Gd-IgA1并不能充分预测IgAN的进展[4,5]。Camilla等人（意大利Regina Margherita大学医院）最近在《美国肾脏病学会临床杂志》上发表的一篇文章中指出，在292名诊断为IgA肾病的患者中，通过高级氧化蛋白产品评估的循环氧化应激水平优于Gd-IgA1水平测定，并能最好地预测进展性肾脏疾病。
Galactose-deficient IgA1 (Gd-IgA1) plays a central role in the pathogenesis of IgA nephropathy (IgAN)[1–3]. However, high levels of circulating Gd-IgA1 are not sufficiently predictive regarding IgAN progression [4, 5]. In a recent publication in the Clinical Journal of the American Society of Nephrology by Camilla et al.(Regina Margherita University hospital, Italy), the circulating oxidative stress level, assessed by advanced oxidation protein products, outperformed Gd-IgA1 level determinations and predicted best the progressive kidney disease in a cohort of 292 patients diagnosed with IgA nephropathy [6].