The isolation of mutants of Aspergillus flavus and A.parasiticus with altered aflatoxin producing ability.
The isolation of mutants of Aspergillus flavus and A.parasiticus with altered aflatoxin producing ability.
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DOI：
10.1080/00362177385190471
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发表时间：
1973-11
期刊：
影响因子：
--
通讯作者：
J. Bennett;L. A. Goldblatt
中科院分区：
文献类型：
--
作者：
J. Bennett;L. A. Goldblatt
影响黄曲霉毒素产生的突变可能有助于研究其生物合成，并有助于了解从自然界分离的真菌菌株的黄曲霉产毒性的广泛变化。提出了两种分离曲霉菌突变体的方法，其中黄曲霉毒素的产生减弱或消失。在一种方法中，基于紫外光下改变的荧光来选择突变体。第二种方法利用突变菌株，该菌株产生黄曲霉毒素和野生型中未检测到的橙红色菌丝体色素。源自该菌株的未着色突变体表现出降低或丧失的黄曲霉毒素生成性。
Mutations affecting the production of aflatoxin might be useful in studying its biosynthesis, and in understanding the wide variation in aflatoxigenicity of fungal strains isolated from nature. Two methods of isolating mutants of Aspergillus in which aflatoxin production is attenuated or lost are presented. In one method mutants are selected on the basis of altered fluorescence under ultraviolet light. The second method utilizes a mutant strain which produces aflatoxin and an orange-red mycelial pigment not detected in the wild type. Unpigmented mutants derived from this strain exhibit lowered or lost aflatoxigenicity.