PREJUNCTIONAL ACTIONS OF SOME NON-DEPOLARIZING BLOCKING-DRUGS
PREJUNCTIONAL ACTIONS OF SOME NON-DEPOLARIZING BLOCKING-DRUGS
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DOI：
10.1111/j.1476-5381.1973.tb08163.x
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发表时间：
1973-01-01
影响因子：
7.3
通讯作者：
BLABER, LC
中科院分区：
文献类型：
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作者：
BLABER, LC
1从猫的肌腱中记录到一连串的终板电位(e.p.ps)。通过切断肌纤维或非去极化阻断药物使肌肉麻痹。2计算了递质的合成、储存和释放的参数：第一种EPP的量子含量。在列车中，可用存储器的大小、释放率、量子大小和可用存储器的充填速率。3Tubocurarine和苯喹降低了可用存储器的充填速率，导致其在高刺激率下耗尽。这被释放分数的增加所抵消，在管库拉林的情况下，这足以满足第一个E.P.的量子含量。4二甲基管库拉宁和潘库溴铵在高刺激率下对储存库的再充盈率和储存库的耗竭有相似的影响，但不增加释放分数。因此，第一个e.p.5利诺卡因的量子含量减少，抑制了商店的再灌装速度，并在高刺激率下耗尽了商店。6提示非去极化药物具有较弱的局部麻醉作用，延缓了钠离子流入神经末梢，从而减慢了储藏室的充填速度。这种影响是由季铵盐头引起的。酚基的存在增加了部分释放，这是由于钙流入神经末梢的增加，或者是由于钙的作用增强。
1Trains of end‐plate potentials (e.p.p.s) have been recorded from the isolated tenuissimus of the cat. The muscle was paralyzed either by transversely cutting the muscle fibres or by non‐depolarizing blocking drugs.2The following parameters of transmitter synthesis, storage and release have been calculated: the quantal content of the first e.p.p. in the train, the size of the available store, fractional release, quantum size, and the rate of refilling of the available store.3Tubocurarine and benzoquinonium depressed the rate of refilling of the available store causing its depletion at high rates of stimulation. This was offset by an increase in fractional release, which in the case of tubocurarine was sufficient for the quantal content of the first e.p.p. to be unchanged.4Dimethyltubocurarine and pancuronium had a similar effect to tubocurarine on the rate of refilling of the store and depletion of the store at high rates of stimulation but did not increase fractional release. There was, therefore, a decrease in the quantal content of the first e.p.p.5Lignocaine depressed the rate of refilling of the store and depleted the store at high rates of stimulation. Fractional release was also depressed.6It is suggested that the non‐depolarizing drugs have a weak local anaesthetic action retarding the influx of sodium into the nerve terminal which slows the rate of refilling of the store. This effect is due to the quaternary ammonium head. The presence of a phenolic group increases fractional release due either to an increased influx of calcium into the nerve terminal or to a potentiation of the actions of calcium.