Desmoplastic Malignant Melanoma
Desmoplastic Malignant Melanoma
复制标题
促纤维增生性恶性黑色素瘤
DOI：
10.1111/j.1346-8138.1988.tb03669.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Y. Ishibashi
中科院分区：
文献类型：
--
作者：
H. Nakagawa;Ai;K. Kikuchi;N. Kurose;M. Kawashima;T. Nogita;Y. Ishibashi
一名86岁的日本女性，在其右脚外侧的先前色素性病变（肢端雀斑样黑色素瘤）上出现无色素性肿瘤。大部分肿瘤由纤维或粘液样基质中的非典型纺锤形细胞组成，是促结缔组织增生性恶性黑色素瘤的特征性表现。免疫组化显示肿瘤细胞S-100蛋白和神经元特异性烯醇化酶阳性。超微结构上，大多数梭形细胞表现出许旺特征，不含黑素体。偶尔的非典型细胞，然而，包含椭圆形的细胞器与微妙的交叉内部条纹，但没有显示施万特征。我们的研究结果进一步支持了这一假设，即促结缔组织增生性恶性黑色素瘤的促结缔组织增生是去分化黑色素瘤细胞获得纤维发生能力的结果。
A 86‐year‐old Japanese woman presented with an amelanotic tumor that had arisen on an antecedent pigmented lesion (acral lentiginous melanoma) on the lateral side of her right foot. The bulk of the tumor was composed of atypical spidle cells in a fibrous or myxoid matrix, pathognomonic of desmoplastic malignant melanoma. Immunohistochemically, neoplastic cells were positive for S‐100 protein and neuron specific enolase. Ultrastructurally, the majority of spindle cells showed Schwannian features and contained no melanosomes. Occasional atypical cells, however, contained ellipsoidal organelles with subtle cross internal striations but did not show Schwannian features. Our findings lend further support to the hypothesis that the desmoplasia in desmoplastic malignant melanoma is the result of acquired fibrogenetic capacities of dedifferentiated melanoma cells.