Excess mortality in acromegaly
Excess mortality in acromegaly
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DOI：
10.1159/000110617
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Holdaway, I. M.
中科院分区：
文献类型：
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作者：
Holdaway, I. M.
背景：肢端肥大症患者生长激素（GH）和胰岛素样生长因子-I（IGIF-I）的产生增加与普通人群的死亡率增加两倍相关。各种研究中标准化死亡率的范围为 1.2 至 3.6。死亡率的预测因素：多变量分析表明，治疗后血清 GH 水平以及在许多研究中血清 IGF-I 水平是最有力的结果预测因素。正常 IGF-I 浓度和随机 GH 水平
Background: Increased production of growth hormone (GH) and insulin-like growth factor-I (IGIF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. Predictors of Mortality: Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF-I concentrations and random GH levels