Rostrolateral prefrontal cortex involvement in relational integration during reasoning
Rostrolateral prefrontal cortex involvement in relational integration during reasoning
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DOI：
10.1006/nimg.2001.0922
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发表时间：
2001-11-01
期刊：
影响因子：
5.7
通讯作者：
Gabrieli, JDE
中科院分区：
文献类型：
--
作者：
Christoff, K;Prabhakaran, V;Gabrieli, JDE
患者和神经影像学研究表明，复杂的推理任务与前额皮质 (PFC) 相关。在这项研究中，我们测试了这样一个假设：关系整合过程，或者同时考虑多个关系，是选择性地招募 PFC 的复杂推理的组成过程。我们使用 fMRI 检查改编自 Raven 渐进矩阵的 0-关系、1-关系和 2-关系问题期间的大脑激活，并假设 PFC 将优先被 2-关系问题类型招募。通过将典型的血流动力学响应函数与与每个试验相关的响应时间 (RT) 进行卷积来建模事件相关的响应。不同分析的结果揭示了相同的模式：PFC 激活特定于 2 关系问题和 1 关系问题之间的比较，而在 1 关系问题和 0 关系问题之间的比较中没有观察到。此外，关系整合过程与双侧前外侧 PFC（RLPFC；外侧区域 10）和右背外侧 PFC（区域 9 和 46）特别相关。左 RLPFC 显示出最大的特异性，即使在比较仅限于与 RT 和准确性匹配的试验之后，在 2 关系问题中仍然优先招募。 RLPFC 和关系整合过程之间的联系可能是由于操纵自生成信息的相关过程，该过程可能表征 RLPFC 功能。 (C) 2001 年学术出版社。
Patient and neuroimaging studies indicate that complex reasoning tasks are associated with the prefrontal cortex (PFC). In this study, we tested the hypothesis that the process of relational integration, or considering multiple relations simultaneously, is a component process of complex reasoning that selectively recruits PFC. We used fMRI to examine brain activation during 0-relational, 1-relational, and 2-relational problems adapted from the Raven's Progressive Matrices and hypothesized that PFC would be preferentially recruited by the 2-relational problem type. Event-related responses were modeled by convolving a canonical hemodynamic response function with the response time (RT) associated with each trial. The results across different analyses revealed the same pattern: PFC activation was specific to the comparison between 2- and 1-relational problems and was not observed in the comparison between 1- and 0-relational problems. Furthermore, the process of relational integration was specifically associated with bilateral rostrolateral PFC (RLPFC; lateral area 10) and right dorsolateral PFC (areas 9 and 46). Left RLPFC showed the greatest specificity by remaining preferentially recruited during 2-relational problems even after comparisons were restricted to trials matched for RT and accuracy. The link between RLPFC and the process of relational integration may be due to the associated process of manipulating self-generated information, a process that may characterize RLPFC function. (C) 2001 Academic Press.