Central corneal thickness and corneal hysteresis associated with glaucoma damage
Central corneal thickness and corneal hysteresis associated with glaucoma damage
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DOI：
10.1016/j.ajo.2005.12.007
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Quigley, HA
中科院分区：
文献类型：
--
作者：
Congdon, NG;Broman, AT;Quigley, HA
目的：我们试图测量中央角膜厚度（CCT）（青光眼损伤的可能危险因素）和角膜滞后（一种拟议的角膜抗变形能力测量）对青光眼损伤各种指标的影响。设计：观察性研究。方法：威尔默青光眼服务的成年患者接受了 Reichert 眼反应分析仪上的滞后测量和 CCT 测量 超声波测厚法。两位青光眼专家（H.A.Q.、N.G.C.）审查了该图表，以确定已知的最高眼压 (IOP)、目标 IOP、诊断、青光眼患病年数、杯盘比 (CDR)、平均缺损 (MD)、模式标准差 (PSD)、青光眼半视野测试 (GHT) 以及是否存在视野进展。 结果：在 230 名受试者中， 平均年龄为 65±14 岁，127 名 (55%) 为女性，161 名 (70%) 为白人，194 名 (85%) 被诊断为原发性开角型青光眼 (POAG) 或疑似 POAG。在多变量广义估计方程模型中，较低的角膜滞后值 (P = .03)（而非 CCT）与视野进展相关。当模型中包含轴向长度时，滞后并不是显着的风险因素 (P = .09)。最近一次检查时，较薄的 CCT (P = .02) 但与较高的 CDR 无关，但与滞后无关。 CCT 和迟滞均与 MD、PSD 或 GHT“超出正常范围”相关。结论：如 CDR 所示，较薄的 CCT 与青光眼损伤状态相关。眼轴长度和角膜滞后与进行性视野恶化有关。
PURPOSE: We sought to measure the impact of central corneal thickness (CCT), a possible risk factor for glaucoma damage, and corneal hysteresis, a proposed measure of corneal resistance to deformation, on various indicators of glaucoma damage.DESIGN: Observational study.METHODS: Adult patients of the Wilmer Glaucoma Service underwent measurement of hysteresis on the Reichert Ocular Response Analyzer and measurement of CCT by ultrasonic pachymetry. Two glaucoma specialists (H.A.Q., N.G.C.) reviewed the chart to determine highest known intraocular pressure (IOP), target IOP, diagnosis, years with glaucoma, cup-to,disk ratio (CDR), mean defect (MD), pattern standard deviation (PSD), glaucoma hemifield test (GHT), and presence or absence of visual field progression.RESULTS: Among 230 subjects, the mean age was 65 14 years, 127 (55%) were female, 161 (70%) were white, and 194 (85%) had a diagnosis of primary open-angle glaucoma (POAG) or suspected POAG. In multi-variate generalized estimating equation models, lower corneal hysteresis value (P = .03), but not CCT, was associated with visual field progression. When axial length was included in the model, hysteresis was not a significant risk factor (P = .09). A thinner CCT (P = .02), but not hysteresis, was associated with a higher CDR at the most recent examination. Neither CCT nor hysteresis was associated with MD, PSD, or GHT "outside normal limits."CONCLUSIONS: Thinner CCT was associated with the state of glaucoma damage as indicated by CDR. Axial length and corneal hysteresis were associated with progressive field worsening.