Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers.
Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers.
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DOI：
10.3389/fimmu.2021.681810
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发表时间：
2021
影响因子：
7.3
通讯作者：
Fang H
中科院分区：
文献类型：
--
作者：
Meng L;Song Z;Liu A;Dahmen U;Yang X;Fang H
由免疫应答诱导的炎症被认为是许多疾病的驱动因素，包括感染和炎性疾病、代谢紊乱和癌症。与免疫应答相关的关键基因的遗传变异，特别是单核苷酸多态性（SNP），可以解释疾病的易感性和临床结果。脂多糖（LPS）结合蛋白（LBP）作为宿主对LPS反应的增强剂发挥作用，LPS是革兰氏本土细菌外膜的主要成分。鉴于LBP在炎症中的关键作用，我们将回顾LBP基因中SNP对感染和炎症性疾病、代谢紊乱和癌症的影响。
Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.
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影响因子：
16.2
作者：
Ghanim H;Abuaysheh S;Sia CL;Korzeniewski K;Chaudhuri A;Fernandez-Real JM;Dandona P
通讯作者：
Dandona P
影响因子：
4.7
作者：
Chang, Cindy M.;Chia, Victoria M.;Berndt, Sonja I.
通讯作者：
Berndt, Sonja I.
影响因子：
14.2
作者：
Daley, Denise;Park, Julie E.;Sandford, Andrew J.
通讯作者：
Sandford, Andrew J.
影响因子：
20.3
作者：
Chien, Jason W.;Boeckh, Michael J.;Clark, Joan G.
通讯作者：
Clark, Joan G.
影响因子：
32.4
作者：
Eckert, Jana K.;Kim, Young J.;Schumann, Ralf R.
通讯作者：
Schumann, Ralf R.