GENES INVOLVED IN REGULATING THE MELANOCYTE AND MELANOBLAST-MELANOCYTE POPULATIONS IN THE EPIDERMIS OF NEWBORN MOUSE SKIN
GENES INVOLVED IN REGULATING THE MELANOCYTE AND MELANOBLAST-MELANOCYTE POPULATIONS IN THE EPIDERMIS OF NEWBORN MOUSE SKIN
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DOI：
10.1002/jez.1402230307
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
HIROBE, T
中科院分区：
文献类型：
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作者：
HIROBE, T
在C57BL/10J和C3H/He小鼠背表皮中，多巴反应阳性的黑素细胞数量从出生到3、4日龄逐渐增加，到30日龄逐渐减少并消失。多巴-前黑色素联合反应阳性的黑素母细胞和黑素细胞的数量保持不变，直到3日龄和4日龄，然后减少。尽管这些群体从出生起的变化具有相似性，但在两个菌株之间这种细胞的数量存在显着差异。C3H/He组黑素细胞和成黑素细胞均少于C57BL/10J组。通过F1、F2和回交配种来了解这种差异的遗传基础。在F2代中，正交后代在两个群体中均表现出中间值。F2代包括C3H/He型、F1型和C57BL/10J型，比例约为0.1%。两种人群的比例都是1:2:1。两个反向回交的亲本型与F1型之比均与两个群体的1:1无显著差异。新生小鼠皮肤背表皮的黑素细胞和成黑素细胞群受半显性基因控制。
In the dorsal epidermis of C57BL/10J and C3H/He mice, the number of melanocytes positive to the dopa reaction increased from birth to 3 or 4 days of age, and then gradually decreased and disappeared by 30 days of age. The number of melanoblasts plus melanocytes positive to the combined dopa-premelanin reaction remained constant until 3 or 4 days of age and then decreased in both strains. Despite the similarity of the change in these populations from birth onwards, there was a significant difference in the number of such cells between the 2 strains. Both melanocytes and melanoblasts in C3H/He were fewer than in C57BL/10J mice. The F1, F2 and backcross matings were performed to gain some information about the genetic basis of the difference. In the F2 generation the offspring from reciprocal crosses exhibited intermediate values in both populations. The F2 generation included the C3H/He type, F1 type and C57BL/10J type in a ratio of .apprx. 1:2:1 in both populations. Both reciprocal backcrosses gave ratios of parent type to F1 type, which did not differ significantly from 1:1 in either population. The melanocyte and melanoblastmelanocyte populations in the dorsal epidermis of newborn mouse skin are controlled by semidominant genes.