Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort
Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort
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DOI：
10.1016/j.jbspin.2015.09.010
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发表时间：
2016-10-01
期刊：
影响因子：
4.2
通讯作者：
Constantin, Arnaud
中科院分区：
文献类型：
--
作者：
Krams, Thomas;Ruyssen-Witrand, Adeline;Constantin, Arnaud
目的：研究是否在发病年龄决定临床，影像学或功能的结果在早期RA.Methods队列：ESPOIR队列是一个多中心队列的早期关节炎患者。我们选择了在前3年随访期间符合2010年ACR/EULAR RA标准的患者。按RA发作时的年龄将患者合并为3组：60岁（晚发性RA [LORA]）。在基线和随访的前3年期间比较以下结果：简单疾病活动指数（SDAI）缓解率、一次额外侵蚀、健康评估问卷残疾指数（HAQ-DI）< 0.5和首次缓解疾病的抗风湿药物（DMARD）继续使用率。我们纳入了698例患者（中位[四分位距]年龄50.3 [39.8-57.2]岁），266例为YORA，314例为IORA，118例为LORA。1年时，YORA组的SDAI缓解率高于IORA和LORA组（P < 0.0001）。在1年（P=0.009）和3年（P=0.017）后，LORA和IORA组至少有一次额外的糜烂大于YORA组。在1年、2年和3年时，YORA组HAQ评分< 0.5的患者比例高于IORA和LORA组（P=0.007）。第一DMARD继续率较低的YORA比其他组在3 years（P=0.005）。结论：在早期RA的队列中，年轻的发病年龄与高缓解率在1年，无放射学进展在3年和低功能评分在3年的随访。(C)2016年法国rhumatologie协会。由Elsevier Masson SAS出版。All rights reserved.
Objectives: To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.Methods: The ESPOIR cohort is a multicenter cohort of patients with early arthritis. We selected patients fulfilling the 2010 ACR/EULAR criteria for RA during the first 3 years of follow-up. Patients were pooled into 3 groups by age at RA onset: 60 years (late-onset RA [LORA]). The following outcomes were compared at baseline and during the first 3 years of follow-up: Simple Disease Activity Index (SDAI) remission rate, one additional erosion, Health Assessment Questionnaire Disability Index (HAQ-DI) < 0.5 and first disease-modifying anti-rheumatic drug (DMARD) continuation rate.Results: We included 698 patients (median [interquartile range] age 50.3 [39.8-57.2] years), 266 YORA, 314 IORA, and 118 LORA. At 1 year, SDAI remission was greater for YORA than IORA and LORA (P < 0.0001). Having at least one additional erosion was greater for LORA and IORA than YORA after 1 year (P=0.009) and 3 years (P=0.017). The proportion of patients with HAQ score < 0.5 was greater for YORA than IORA and LORA at 1 (P=0.007), 2 and 3 years. First DMARD continuation rate was lower for YORA than other groups during the 3 years (P=0.005).Conclusions: In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1 year, no radiographic progression at 3 years and low functional score during 3-year follow-up. (C) 2016 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.