Ultrasound interstitial thermal therapy (USITT) for the treatment of uterine myomas.
Ultrasound interstitial thermal therapy (USITT) for the treatment of uterine myomas.
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超声间质热疗法（USITT）用于治疗子宫肌瘤。
DOI：
10.1117/12.703220
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Burdette,EClif
中科院分区：
文献类型：
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作者：
Nau,WilliamH;Diederich,ChrisJ;Simko,Jeff;Juang,Titania;Jacoby,Alison;Burdette,EClif
子宫肌瘤（肌瘤）是女性最常见的盆腔肿瘤，也是子宫切除术的主要原因。症状可能很严重，传统的治疗方法包括手术切除子宫（子宫切除术）或肌瘤（肌瘤切除术）。间质超声技术已被证明是热疗和高温热疗在治疗良性和恶性肿瘤的潜力。这些超声设备提供有利的能量穿透，允许在短时间内治疗大量组织，以及加热的轴向和角度控制，以使热治疗符合目标组织，同时保护周围组织免受热损伤。本项目的目的是评价间质超声用于控制子宫肌瘤热凝固。使用管状换能器制造多元件施用器，其中一些被扇形化以产生180°定向加热模式，并且与水冷却集成。在常规子宫肌瘤切除术后获得人子宫肌瘤，并在距施用器0.5、1.0、1.5、2.0、2.5和3.0 cm处用热电偶进行仪器化。每个元件施加8-15 W的功率水平，加热时间长达15分钟。结果表明，治疗温度>50° C和细胞毒性热剂量（t43）从施用器径向延伸超过2cm（直径> 4cm）。预计该系统将对子宫肌瘤的治疗做出重大贡献。
Uterine myomas (fibroids) are the most common pelvic tumors occurring in women, and are the leading cause of hysterectomy. Symptoms can be severe, and traditional treatments involve either surgical removal of the uterus (hysterectomy), or the fibroids (myomectomy). Interstitial ultrasound technologies have demonstrated potential for hyperthermia and high temperature thermal therapy in the treatment of benign and malignant tumors. These ultrasound devices offer favorable energy penetration allowing large volumes of tissue to be treated in short periods of time, as well as axial and angular control of heating to conform thermal treatment to a targeted tissue, while protecting surrounding tissues from thermal damage. The goal of this project is to evaluate interstitial ultrasound for controlled thermal coagulation of fibroids. Multi-element applicators were fabricated using tubular transducers, some of which were sectored to produce 180° directional heating patterns, and integrated with water cooling. Human uterine fibroids were obtained after routine myomectomies, and instrumented with thermocouples spaced at 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 cm from the applicator. Power levels ranging from 8-15 W per element were applied for up to 15 minute heating periods. Results demonstrated that therapeutic temperatures >50° C and cytotoxic thermal doses (t43) extended beyond 2 cm radially from the applicator (>4 cm diameter). It is anticipated that this system will make a significant contribution toward the treatment of uterine fibroids.