New therapeutic targets in alcoholic hepatitis.
New therapeutic targets in alcoholic hepatitis.
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DOI：
10.1007/s12072-015-9701-6
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发表时间：
2016-07
影响因子：
6.6
通讯作者：
Bataller R
中科院分区：
文献类型：
--
作者：
Arsene D;Farooq O;Bataller R
酒精性肝病（ALD）是全球肝脏相关发病率和死亡率的主要原因。ALD包括一系列疾病，包括无症状脂肪变性、脂肪性肝炎、纤维化、肝硬化及其相关并发症，以及酒精性肝炎的急性慢性状态。虽然多学科的努力继续旨在遏制这一系列疾病的进展，但迫切需要将我们的努力集中在酒精性肝炎（AH）的有效治疗干预上，这是ALD的最严重形式。AH的特点是突然发展的黄疸和并发症相关的肝功能不全和门静脉高压症的患者大量饮酒。重度AH患者的死亡率非常高（3个月时为20-50%）。目前的治疗方案是有限的。新疗法的开发需要在人类样本和合适的动物模型中进行转化研究，以重现人类AH的临床和组织学特征。本文综述了AH的临床症状、临床前转化工具以及分子和细胞水平的发病机制，旨在确定潜在治疗干预的新靶点。
Alcoholic liver disease (ALD) is a leading cause of liver related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute on chronic state of alcoholic hepatitis. While multidisciplinary efforts continue to be aimed at curbing progression of this spectrum of disorders, there is an urgent need to focus our efforts on effective therapeutic interventions for alcoholic hepatitis (AH), the most severe form of ALD. AH is characterized by an abrupt development of jaundice and complications related to liver insufficiency and portal hypertension in patients with heavy alcohol intake. The mortality of patients with severe AH is very high (20–50% at 3 months). The current therapeutic regimens are limited. The development of new therapies requires translational studies in human samples and suitable animal models that reproduce clinical and histological features of human AH. This review article summarizes the clinical syndrome, pre-clinical translational tools, and pathogenesis of AH at a molecular and cellular level, with the aim to identify new targets of potential therapeutic intervention.