PROLONGED CARRIAGE OF CLOSTRIDIUM-DIFFICILE IN HIRSCHSPRUNGS-DISEASE
PROLONGED CARRIAGE OF CLOSTRIDIUM-DIFFICILE IN HIRSCHSPRUNGS-DISEASE
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DOI：
10.1136/adc.69.2.221
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发表时间：
1993-08-01
影响因子：
5.2
通讯作者：
SPITZ, L
中科院分区：
文献类型：
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作者：
HARDY, SP;BAYSTON, R;SPITZ, L
在一项前瞻性纵向研究中，对艰难梭菌在先天性巨结肠患儿腹泻病因学中的作用进行了研究。在64例先天性巨结肠患儿中，腹泻组和非腹泻组的艰难梭菌分离率无显著性差异（分别为32%和26%），而对照组中腹泻组和非腹泻组的艰难梭菌分离率相似（分别为27%和16%）。四组儿童中产生毒素B的菌株数量相似，对照组儿童中艰难梭菌在12个月龄时消失，而在12个月龄以上的先天性巨结肠患儿中，艰难梭菌可反复分离。这些发现有助于调和目前关于先天性巨结肠症相关性小肠结肠炎中艰难梭菌发生率的相互矛盾的报道。
The role of Clostridium difficile in the aetiology of diarrhoea in children with Hirschsprung's disease was investigated in a prospective longitudinal study. In 64 children with Hirschsprung's disease no significant difference was found in the isolation rate of C difficile in patients with diarrhoea (32%) and without diarrhoea (26%).Comparable isolation rates were found in 47 control children with and without diarrhoea (27% and 16% respectively). The number of strains producing toxin B was similar in the four groups of children.In contrast to the disappearance of C difficile by 12 months of age in the control groups of children, C difficile could be repeatedly isolated from a proportion of children with Hirschsprung's disease over 12 months of age. These findings help to reconcile the existing contradictory reports on the incidence of C difficile in Hirschsprung's disease associated enterocolitis.