Ferroptosis and Its Role in Diverse Brain Diseases.

Ferroptosis and Its Role in Diverse Brain Diseases.
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铁毒性及其在各种脑部疾病中的作用。

DOI:
10.1007/s12035-018-1403-3
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发表时间:
2019-07
影响因子:
5.1
通讯作者:
Wang J
Wang J
中科院分区:
医学2区
文献类型:
--
作者:
Weiland A;Wang Y;Wu W;Lan X;Han X;Li Q;Wang J

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铁凋亡是最近发现的一种铁调节的非凋亡性细胞死亡形式。其特征在于脂质活性氧的细胞积累,最终导致氧化应激和细胞死亡。虽然首先在癌细胞中发现,但铁凋亡已被证明在几种神经系统疾病中具有重要意义,如缺血性和出血性中风,阿尔茨海默病和帕金森病。本文综述了目前对铁下垂的研究,其潜在的机制,以及它在不同的神经系统疾病的进展中的作用。了解铁下垂的作用可以提供有关治疗和预防这些毁灭性疾病的有价值的信息。
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer’s disease, and Parkinson’s disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
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