Memory allocation mechanisms underlie memory linking across time.

Memory allocation mechanisms underlie memory linking across time.
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内存分配机制是跨时间内存链接的基础。

DOI:
10.1016/j.nlm.2018.02.021
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发表时间:
2018-09
影响因子:
2.7
通讯作者:
Silva AJ
Silva AJ
中科院分区:
心理学4区
文献类型:
--
作者:
Sehgal M;Zhou M;Lavi A;Huang S;Zhou Y;Silva AJ

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记忆是动态的。对世界的内聚表征要求记忆随着时间的推移而改变,与其他记忆联系起来,并最终整合到更大的语义知识框架中。虽然有相当多的文献是关于单一记忆是如何编码、检索和更新的,但人们对记忆链接的机制知之甚少,即不同记忆在几个小时或几天内的链接和整合。在这篇综述中,我们提出的证据表明,特定的记忆分配机制,如CREB和内在兴奋性的变化,确保记忆存储的方式,促进有效的回忆和链接在以后的时间。除了CREB和内在兴奋性,我们还审查了一些其他现象与记忆链接的潜在作用。
Memories are dynamic in nature. A cohesive representation of the world requires memories to be altered over time, linked with other memories and eventually integrated into a larger framework of sematic knowledge. Although there is a considerable literature on how single memories are encoded, retrieved and updated, little is known about the mechanisms that govern memory linking i.e. linking and integration of various memories across hours or days. In this review, we present evidence that specific memory allocation mechanisms, such as changes in CREB and intrinsic excitability, ensure memory storage in ways that facilitate effective recall and linking at a later time. Beyond CREB and intrinsic excitability, we also review a number of other phenomena with potential roles in memory linking.
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