SARS-CoV-2 Proteins Induce Endotoxin Tolerance Hallmarks: A Demonstration in Patients with COVID-19
SARS-CoV-2 Proteins Induce Endotoxin Tolerance Hallmarks: A Demonstration in Patients with COVID-19
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DOI：
10.4049/jimmunol.2001449
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发表时间：
2021-07-01
影响因子：
4.4
通讯作者：
Lopez-Collazo, Eduardo
中科院分区：
文献类型：
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作者：
Avendano-Ortiz, Jose;Lozano-Rodriguez, Roberto;Lopez-Collazo, Eduardo
根据大量报道的队列，在几乎所有死亡的COVID-19患者中都观察到败血症。我们和其他人已经描述败血症，在其他病理中，是一种内毒素耐受性（ET）相关的疾病。在这项研究中，我们证明了在存在SARS-CoV-2蛋白的情况下培养健康志愿者的人血细胞可诱导ET标志，包括促炎细胞因子产生受损，MHC II类（HLA-DR）表达降低，T细胞增殖不良，以及吞噬和组织重塑增强。此外，我们报告了COVID-19患者中存在SARS-CoV-2血液循环蛋白，以及这些水平如何与ET状态、血浆中SARS-CoV-2病毒RNA的存在以及继发感染患者比例的增加相关。
According to a large number of reported cohorts, sepsis has been observed in nearly all deceased patients with COVID-19. We and others have described sepsis, among other pathologies, to be an endotoxin tolerance (ET) -related disease. In this study, we demonstrate that the culture of human blood cells from healthy volunteers in the presence of SARS-CoV-2 proteins induced ET hallmarks, including impairment of proinflammatory cytokine production, low MHC class II (HLA-DR) expression, poor T cell proliferation, and enhancing of both phagocytosis and tissue remodeling. Moreover, we report the presence of SARS-CoV-2 blood circulating proteins in patients with COVID-19 and how these levels correlate with an ET status, the viral RNA presence of SARS-CoV-2 in plasma, as well as with an increase in the proportion of patients with secondary infections.