Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico
Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico
复制标题
DOI：
10.1186/1476-069x-13-97
复制
发表时间：
2014-11-19
影响因子：
6
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Lewis, Ryan C.;Cantonwine, David E.;Meeker, John D.
背景：接触杀虫剂对母亲和胎儿有潜在的不良健康风险。方法：测定了驱虫剂N-N-二乙基-间甲苯酰胺(DEET)及其两种代谢物[3-二乙基氨基甲酰苯甲酸(DCBA)和N，N-二乙基-3-羟基甲基苯甲酰胺(DHMB)]、四种拟除虫菊酯类杀虫剂代谢物[4-氟-3-苯氧基苯甲酸(4-F-3-PBA)、3-苯氧基苯甲酸(3-PBA)、3-苯氧基苯甲酸(3-PBA)；在三个不同的时间点(怀孕20+/-2周、24+/-2周和28+/-2周)，对54名波多黎各孕妇进行了三种氯苯氧基除草剂[2，4-二氯苯氧基乙酸(2，4-D)和2，4，5-三氯苯氧基乙酸(2，4，5-T)]的研究，结果表明，这些除草剂包括三种不同的除草剂：trans-3-(2，2-dichlorovinyl)-2，2-dimethylcyclopropane羧酸(反式-DCCA)、顺-3-(2，2-二溴乙烯基)-2，2-二甲基环丙烷羧酸(顺-DBCA)和两种氯苯氧基除草剂[2，4-二氯苯氧乙酸(2，4-D)和2，4，5-三氯苯氧乙酸(2，4，5-T)]。我们计算了生物标志物浓度的分布，并将它们与美国普通人群中育龄妇女的浓度进行了比较，并估计了这些重复测量的受试者内的时间变异性。我们还收集了过去48小时内人口统计学、精选水果、蔬菜和豆类的消费以及与害虫相关的问题的问卷数据，并检查了这些变量与生物标志物浓度之间的关系。结果：我们发现，在美国大陆，DEET、3-PBA、反式-DCCA和2，4-D的第95个百分位数的尿液浓度低于育龄妇女，而4-F-3-PBA、顺式-DBCA和2，4，5-T的尿液浓度在第95个百分位数相似。DCBA是在50%的样本中检测到的唯一尿液生物标志物，在怀孕期间显示出中等到良好的重复性(组内相关系数：0.60)。女性更有可能(p
Background: There are potential adverse health risks to the mother and fetus from exposure to pesticides. Thus, studies of exposure to pesticides among pregnant women are of interest as they will assist with understanding the potential burden of exposure globally, identifying sources of exposure, and designing epidemiology studies.Methods: We measured urinary concentrations of the insect repellent N-N-diethyl-meta-toluamide (DEET) and two of its metabolites [3-diethyl-carbamoyl benzoic acid (DCBA) and N,N-diethyl-3-hydroxymethylbenzamide (DHMB)], four pyrethroid insecticide metabolites [4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA); 3-phenoxybenzoic acid (3-PBA); trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA); and cis-3-(2,2-dibromovinyl)-2,2- dimethylcyclopropane carboxylic acid (cis-DBCA)], and two chlorophenoxy herbicides [2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)] in 54 pregnant women from Puerto Rico at three separate time points (20 +/- 2 weeks, 24 +/- 2 weeks, and 28 +/- 2 weeks of gestation). We calculated the distributions of the biomarker concentrations and compared them to those of women of reproductive age from the general U.S. population where available, and estimated the within-subject temporal variability of these repeated measurements. We also collected questionnaire data on demographics, consumption of select fruits, vegetables, and legumes in the past 48-hr, and pest-related issues, and associations between these variables and biomarker concentrations were examined.Results: We found that 95th percentile urinary concentrations of DEET, 3-PBA, trans-DCCA, and 2,4-D were lower than women of reproductive age on the U. S. mainland, whereas 95th percentile urinary concentrations of 4-F-3-PBA, cis-DBCA, and 2,4,5-T were similar. DCBA, the only urinary biomarker detected in >50% of the samples, showed fair to good reproducibility across pregnancy (intraclass correlation coefficient: 0.60). Women were more likely (p