Gastrointestinal absorption of folates and antifolates.
Gastrointestinal absorption of folates and antifolates.
复制标题
叶酸和抗叶酸剂的胃肠道吸收。
DOI：
10.1016/0163-7258(83)90034-7
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发表时间：
1983
影响因子：
13.5
通讯作者：
Rosenberg,IH
中科院分区：
文献类型：
--
作者：
Selhub,J;Dhar,GJ;Rosenberg,IH
1945年蝶酰谷氨酸（叶酸）的合成不仅为研究这种维生素的生理和代谢提供了纯底物，而且还为抗叶酸化合物的合成开辟了道路。这些是第一批用于癌症化疗的药物。一段时间以来，叶酸吸收的研究实际上仅限于合成叶酸的研究，但逐渐地，其他形式的叶酸（包括聚谷氨酰叶酸）也受到分析。只是在最近几年，甲氨蝶呤吸收的研究已经进行。现在很清楚，甲氨蝶呤和叶酸在肠道中的转运是由相同的机制介导的。在这篇关于叶酸和抗叶酸剂吸收的文章中，将对叶酸的研究进行详细分析，然后对抗叶酸剂底物的实验进行评估。
The synthesis of pteroylglutamic (folic) acid in 1945 not only provided pure substrate to make possible studies on the physiology and metabolism of this vitamin, but also led the way to the synthesis of antifolate compounds. These were among the first drugs to be used in cancer chemotherapy. For some time, studies of folate absorption were virtually limited to studies with synthetic folic acid but gradually other forms of folate including polyglutamyl folates were subjected to analysis. It is only in recent years that studies of methotrexate absorption have been undertaken. It is now clear that the transport of methotrexate and the folates in the intestine is mediated by the same mechanism. In this article on folate and antifolate absorption, a detailed analysis of the studies with folic acid will be presented and this will be followed by an evaluation of the experiments with antifolate substrates.