High prevalence of autoimmune phenomena in hepatitis C virus antibody positive patients with lymphoproliferative and connective tissue disorders
High prevalence of autoimmune phenomena in hepatitis C virus antibody positive patients with lymphoproliferative and connective tissue disorders
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患有淋巴组织增生和结缔组织疾病的丙型肝炎病毒抗体阳性患者中自身免疫现象的发生率较高
DOI：
10.1046/j.1365-2141.1996.7542376.x
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发表时间：
1996
影响因子：
6.5
通讯作者：
F. Caligaris‐cappio
中科院分区：
文献类型：
--
作者：
S. Pivetti;A. Novarino;F. Merico;M. Tiziana Bertero;M. Brunetto;F. Bonino;F. Caligaris‐cappio
本研究的目的是探讨丙型肝炎病毒（HCV）是否会干扰免疫系统的自身反应性。我们研究了300例患者中抗HCV患病率与实验室和/或临床自身免疫性特征之间的关系：淋巴细胞恶性肿瘤（167例）和自身免疫性疾病（结缔组织疾病100例；特发性血小板减少性紫癜（ITP） 33例）。作为对照，乙型肝炎表面抗原（HBV）和抗乙型肝炎核心抗原（anti - HBc）与相同参数相关。抗HCV和抗HBV分别在68/300（22.6%）和70/300（24.6%）的患者中检测到。HCV患病率在淋巴增生性疾病中为18%（抗HBc 28.1%），在结缔组织疾病中为26%（抗HBc 16.3%）。在ITP病例中，12/33（36.4%）为抗HCV+， 10/33（30.3%）为抗HBc+。在24/30（80%）伴有淋巴细胞增生性疾病的抗HCV阳性患者中，至少检测到一种血清学或临床自身免疫异常。相反，只有10/45（22.2%）伴有淋巴增生性疾病的抗HBc+患者至少有一项血清学或临床异常（P < 0.0001）。在淋巴增生性疾病和结缔组织疾病中，HCV患病率与自身免疫改变数量之间存在统计学意义上的相关性，而抗HBc没有发现这一点。这些数据表明，HCV可能使免疫系统倾向于产生自身抗体，也支持了一些ITP病例可能与HCV和HBV感染有关的可能性。
The aim of this study was to investigate whether hepatitis C virus (HCV) may perturb the immune system towards autoreactivity. We studied the relationship between the prevalence of anti‐HCV and the presence of laboratory and/or clinical autoimmune features in 300 patients: lymphoid malignancies (167) and autoimmune disorders (connective tissue diseases 100; idiopathic thrombocytopenic purpura (ITP) 33). As a control, hepatitis B surface antigen (HBV) and anti‐hepatitis B core antigen (anti‐HBc) were related to the same parameters. Anti‐HCV and anti‐HBV were detected in 68/300 (22.6%) and 70/300 (24.6%) patients, respectively. HCV prevalence was 18% in lymphoproliferative disorders (anti‐HBc 28.1%) and 26% in connective tissue disease (anti‐HBc 16.3%). Among ITP cases, 12/33 (36.4%) were anti‐HCV+ and 10/33 (30.3%) anti‐HBc+. In 24/30 (80%) anti‐HCV+ patients with lymphoproliferative disorders at least one serologic or clinical autoimmune abnormality was detected. To the contrary, only 10/45 (22.2%) anti‐HBc+ patients with lymphoproliferative disorders had at least one serologic or clinical abnormality (P < 0.0001). A statistically significant correlation was observed between HCV prevalence and the number of autoimmune alterations in both lymphoproliferative and connective tissue disorders, which was not found for anti‐HBc. These data suggest that HCV may skew the immune system toward the production of autoantibodies and also support the possibility that some cases of ITP may be linked to both HCV and HBV infection.
影响因子：
20.3
作者：
T. Kipps;D. Carson
通讯作者：
T. Kipps;D. Carson