Dietary lignan intake and androgen receptor expression in breast tumors.
Dietary lignan intake and androgen receptor expression in breast tumors.
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膳食木脂素摄入量和乳腺肿瘤中雄激素受体的表达。
DOI：
10.1007/s10552-014-0504-1
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
McCann,SusanE
中科院分区：
文献类型：
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作者：
Williams,AnnaLynnM;Bonner,Matthew;Ochs-Balcom,HeatherM;Hwang,Helena;Morrison,Carl;McCann,SusanE
目的木脂素是西方饮食中常见的一类植物雌激素，在流行病学研究中已被认为与降低乳腺癌风险有关。与雌激素受体类似，雄激素受体(AR)是乳腺肿瘤的预后因素，也可能受到木脂素的影响。然而，很少有研究在乳腺癌病因学的背景下研究这种联系。方法在Roswell Park癌症研究所(RPCI)数据库和生物信息库(DBBR)中收集216例乳腺癌患者的肿瘤组织、流行病学和临床资料，这些资料均经组织学证实。平均而言，来自每个参与者的三个肿瘤核心被组装成组织微阵列。免疫组织化学染色后，训练有素的RPCI病理学家确定每个核心的AR状态。结果膳食木脂素摄入量与AR表达呈弱正相关[β(SE)27.6(17.0)，p0.10]，不同AR表达类别间木脂素摄入量无显著差异(p=0.09，r2=0.35)。结论我们的研究结果不支持膳食木脂素摄入量与AR表达之间的明确关系。据我们所知，这项研究是第一次检测饮食中木脂素摄入量和AR在乳腺肿瘤中的表达。需要在更大、更具代表性的样本中进行进一步研究，以确定木脂素摄入量是否真的与AR表达有关。
PurposeLignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors.MethodsTumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR.ResultsWe observed a weak positive association between dietary lignans and AR expression [β(SE) 27.6 (17.0),p0.10], and there was no significant difference in lignan intake across categories of AR expression (p= 0.09,R2= 0.35).ConclusionOur results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.