The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study.
The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study.
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DOI：
10.1186/1471-244x-4-42
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发表时间：
2004-12-09
期刊：
影响因子：
4.4
通讯作者：
McGuffin P
中科院分区：
文献类型：
--
作者：
Farmer A;Breen G;Brewster S;Craddock N;Gill M;Korszun A;Maier W;Middleton L;Mors O;Owen M;Perry J;Preisig M;Rietschel M;Reich T;Jones L;Jones I;McGuffin P
抑郁网络研究 (DeNt) 是一项多中心研究，旨在识别与白种人家庭中单相抑郁易感性相关的基因和/或基因座。本研究介绍了从欧洲和美国 8 个不同地点招募的前 470 对受影响兄弟姐妹的方法和社会人口统计细节。符合《诊断和统计手册》第 4 版 (DSM-IV) 或《国际疾病分类》第 10 版 (ICD-10) 中度或重度复发性单相抑郁标准的先证者，并且至少有一个受类似影响的兄弟姐妹有资格参加该研究。对所有受试者进行了详细的临床和心理评估，包括使用神经精神病学临床评估表进行访谈。从所有参与者身上采集血样，提取 DNA 进行连锁分析。不同的站点根据当地的医疗保健组织使用不同的招募策略，但尽管如此，不同站点之间招募的受试者仍存在显着的相似性。尽管波恩中心的受试者发病年龄和访谈年龄均明显偏大，但就整个样本而言，接受访谈的受试者年龄在 40 多岁，并且在 20 多岁时经历了复发性抑郁症的发作。初步基因组筛查能够包括 944 名受试者中的 929 名 (98.4%)，这些受试者通过 932 个常染色体和 544 个 X 染色体标记进行分型。本文描述了多中心 DeNT 研究第一波基因分型中包括的 414 个家庭的受试者的方法和特征。该研究的最终目标是从大约 1200 个家庭中收集受影响的兄弟姐妹对。
The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America. Probands fulfilling either the Diagnostic and Statistical Manual 4th edition (DSM-IV) or the International Classification of Diseases 10th edition (ICD-10) criteria for recurrent unipolar depression of moderate or severe degree and who had at least one similarly affected sibling were eligible for the study. Detailed clinical and psychological assessments were undertaken on all subjects including an interview using the Schedules for Clinical Assessment in Neuropsychiatry. Blood samples were collected from all participants to extract DNA for linkage analysis. The different sites used different recruitment strategies depending on local health care organisation but despite this there was remarkable similarity across sites for the subjects recruited. Although the Bonn site had significantly older subjects both for age of onset and age at interview, for the sample as a whole, subjects were interviewed in their mid-40s and had experienced the onset of their recurrent depression in their 20s. Preliminary genome screening was able to include 929 out of the 944 subjects (98.4%) typed at 932 autosomal and 544 X chromosome markers This paper describes the methodology and the characteristics of the subjects from the 414 families included in the first wave of genotyping from the multi-site DeNT study. Ultimately the study aims to collect affected sibling pairs from approximately 1200 families.