Anthropometric Measures and the Risk of Endometrial Cancer, Overall and by Tumor Microsatellite Status and Histological Subtype
Anthropometric Measures and the Risk of Endometrial Cancer, Overall and by Tumor Microsatellite Status and Histological Subtype
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DOI：
10.1093/aje/kws434
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发表时间：
2013-06-15
影响因子：
5
通讯作者：
Cook, Linda S.
中科院分区：
文献类型：
--
作者：
Amankwah, Ernest K.;Friedenreich, Christine M.;Cook, Linda S.
肥胖是子宫内膜癌的一个既定危险因素，但对于子宫内膜癌亚型的这种相关性尚不清楚。我们根据微卫星状态（微卫星稳定（MSS）与微卫星不稳定（MSI））和组织学（I型与II型）评估了近期和成年肥胖与子宫内膜癌亚型的相关性。分析基于在加拿大阿尔伯塔省进行的一项基于人群的病例对照研究（524例病例和1，032例对照）（20022006），包括以下亚型分组：MSS 337和MSI 130; I型458和II型66。Logistic和多分类Logistic回归分别用于估计总体子宫内膜癌和子宫内膜癌亚型的优势比和95个置信区间。除II型外，所有亚型子宫内膜癌的风险均随所有人体测量特征的增加而增加。MSI肿瘤的风险明显强于MSS肿瘤;高（30）体重指数的风险（体重（kg）/身高（m）（2））对于MSI肿瘤显著更强（比值比4.96，95置信区间：2.76，8.91）比MSS肿瘤（比值比2.33，95置信区间：1.66，3.28）（P-异质性0.02）。肥胖与大多数子宫内膜癌亚型相关，需要进一步研究以阐明具有高体重指数的MSI亚型风险更高的生物学机制。
Obesity is an established risk factor for endometrial cancer, but this association is not well understood for subtypes of endometrial cancer. We evaluated the association of recent and adult-life obesity with subtypes of endometrial cancer based on microsatellite status (microsatellite-stable (MSS) vs. microsatellite-instable (MSI)) and histology (type I vs. type II). Analyses were based on a population-based case-control study (524 cases and 1,032 controls) conducted in Alberta, Canada (20022006) and included the following groupings of subtypes: MSS 337 and MSI 130; type I 458 and type II 66. Logistic and polytomous logistic regression were used to estimate odds ratios and 95 confidence intervals for overall endometrial cancer and subtypes of endometrial cancer, respectively. The risks of all subtypes of endometrial cancer, except type II, increased with an increase in all of the anthropometric characteristics examined. The risks for MSI tumors were suggestively stronger than those for MSS tumors; the risk with high (30) body mass index (weight (kg)/height (m)(2)) was significantly stronger for MSI tumors (odds ratio 4.96, 95 confidence interval: 2.76, 8.91) than for MSS tumors (odds ratio 2.33, 95 confidence interval: 1.66, 3.28) (P-heterogeneity 0.02). Obesity is associated with most subtypes of endometrial cancer, and further studies are warranted to elucidate the biological mechanisms underlying the stronger risk for the MSI subtype with a high body mass index.