Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma
Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma
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DOI：
10.1016/j.jcjo.2017.12.013
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发表时间：
2018-10-01
影响因子：
4.2
通讯作者：
Damji, Karim F.
中科院分区：
文献类型：
--
作者：
Arora, Sourabh;Maeda, Masahiro;Damji, Karim F.
目的：确定采用 Trabectome 进行经内小梁切除术治疗青少年开角型青光眼 (JOAG) 患者的有效性和安全性。设计：前瞻性队列研究。方法：评估接受经内小梁切除术的 2 个患者组的 12 个月结果：第 1 组，先前未接受过切口手术的眼睛；第 2 组，之前接受过切开式白内障或青光眼手术。结果：第 1 组，40 只眼睛（平均年龄 31 +/- 7 岁），12 个月时眼压 (10P) 较基线 27.4 mm Hg 显着降低 10.6 mm Hg (p = 0.01)，青光眼药物数量减少 0.4 (p = 0.80）。研究期间有四只眼睛（10%）需要进行二次青光眼手术。第 2 组，20 只眼睛（平均年龄 27 +/- 8 岁），与基线 27.1 mm Hg 相比，!OP 显着降低 8.8 mm Hg (p = 0.06)，并且青光眼药物的数量减少了 1.4 (p = 0.36)。该组中有 5 只眼睛 (25%) 在 12 个月内接受了二次青光眼手术。结论：经过 1 年的随访，经内小梁切除术似乎是 JOAG 患者有效且安全的干预措施；然而，在接受经内小梁切除术作为主要手术的患者中，可能不会观察到局部药物使用的减少。
Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients.Design: Prospective cohort study.Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery.Results: Group 1, 40 eyes (average age 31 +/- 7 years), had a significant reduction in intraocular pressure (10P) of 10.6 mm Hg at 12 months from a baseline of 27.4 mm Hg (p = 0.01), and the number of glaucoma medications reduced by 0.4 (p = 0.80). Four eyes (10%) within the study period required a secondary glaucoma surgery. Group 2, 20 eyes (average age 27 +/- 8 years), had a significant reduction in !OP of 8.8 mm Hg from a baseline of 27.1 mm Hg (p = 0.06), and the number of glaucoma medications reduced by 1.4 (p = 0.36). Five eyes (25%) from this group underwent a secondary glaucoma surgery within 12 months.Conclusion: After 1 year of follow-up, ab interno trabeculectomy appears to be an effective and safe intervention for patients with JOAG; however, a reduction in use of topical medications may not be observed in those receiving ab interno trabeculectomy as a primary procedure.