Simulation of bone tissue formation within a porous scaffold under dynamic compression
Simulation of bone tissue formation within a porous scaffold under dynamic compression
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DOI：
10.1007/s10237-010-0199-5
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Lacroix, Damien
中科院分区：
文献类型：
--
作者：
Milan, Jean-Louis;Planell, Josep A.;Lacroix, Damien
提出了一种机械调节计算模型，用于预测微 CT 渲染的多孔聚合物支架内整体动态压缩机械刺激的骨组织形成。模拟了 0.0025-0.025 s(-1) 时 0.5-5% 的动态压缩。还通过施加 1 至 70 N 的力斜坡来执行力控制的动态压缩。该模型预测在 0.5-1% 的应变水平和 0.0025-0.005 s(-1) 的应变速率下会形成均匀的成熟骨组织。在较高水平的应变和应变率下，支架表现出异质机械行为，导致形成具有成熟骨和纤维组织混合物的异质组织。在力控制的动态压缩下也预测了纤维组织层，尽管在应变控制的压缩过程中发现相同的力大小仅促进成熟骨。该模型表明，多孔支架内骨组织形成的机械刺激密切取决于加载历史以及支架在局部和全局尺度上的机械行为。
A computational model of mechanoregulation is proposed to predict bone tissue formation stimulated mechanically by overall dynamical compression within a porous polymeric scaffold rendered by micro-CT. Dynamic compressions of 0.5-5% at 0.0025-0.025 s(-1) were simulated. A force-controlled dynamic compression was also performed by imposing a ramp of force from 1 to 70 N. The model predicts homogeneous mature bone tissue formation under strain levels of 0.5-1% at strain rates of 0.0025-0.005 s(-1). Under higher levels of strain and strain rates, the scaffold shows heterogeneous mechanical behaviour which leads to the formation of a heterogeneous tissue with a mixture of mature bone and fibrous tissue. A fibrous tissue layer was also predicted under the force-controlled dynamic compression, although the same force magnitude was found promoting only mature bone during a strain-controlled compression. The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.