Opioid tolerance and hyperalgesia
Opioid tolerance and hyperalgesia
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DOI：
10.1016/j.mcna.2006.10.003
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发表时间：
2007-03-01
影响因子：
5.9
通讯作者：
Mao, Jianren
中科院分区：
文献类型：
--
作者：
Chang, Grace;Chen, Lucy;Mao, Jianren
阿片类药物已成功用于治疗急性疼痛和癌症相关疼痛。对副作用、耐受性、依赖性、成瘾性和痛觉过敏的担忧限制了阿片类药物用于慢性非恶性疼痛的治疗。本文将回顾有关阿片类药物引起的痛觉过敏、耐受性和依赖性的临床和临床前研究的最新信息。这些问题在临床阿片类药物治疗的影响也将进行讨论。
Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.