Biomarkers of endometrial receptivity - A review
Biomarkers of endometrial receptivity - A review
复制标题
DOI：
10.1016/s0143-4004(03)00184-x
复制
发表时间：
2003-10-01
期刊：
影响因子：
3.8
通讯作者：
Mantese, JC
中科院分区：
文献类型：
--
作者：
Cavagna, M;Mantese, JC
着床是一种涉及胚胎和母体子宫内膜之间相互作用的现象。在月经周期中，有一段短暂而精确的时间，在这段时间内母胚相互作用是最佳的，并以胚泡粘附和侵入孕酮诱导的分泌型子宫内膜而达到高潮。这个时期被称为着床窗口或植入窗口。在着床窗口期，子宫内膜上皮细胞形态发生变化，其特征是出现称为胞饮突的膜突起。胞饮突是一种依赖于孕酮的细胞器，在自然月经周期的第20天和第21天之间出现，就像顶端的细胞突起。有许多因素可以调节植入窗和胞饮突外观的典型变化。胚胎和母体的生长因子和细胞因子、降钙素、HOX基因和细胞粘附分子的表达可能在植入现象中起主要作用。细胞因子作为化学信使发挥作用，并可作为子宫容受性的生物标志物。了解这些生物标志物的功能及其在确定女性着床窗口中的作用，将有助于我们更有效地诊断和治疗不孕夫妇。(C)2003年由爱思唯尔有限公司出版
Implantation is a phenomenon that involves an interaction between the embryo and maternal endometrium. There is, in the menstrual cycle, a short and precise period of time in which the maternal-embryonic interaction is optimal and culminates with adhesion and invasion of the blastocyst into the progesterone-induced secretory endometrium. This period is called nidation or implantation window. In the implantation window changes occur in endometrial epithelial morphology, characterized by the appearance of membrane projections called pinopodes. Pinopodes are progesterone-dependent organelles, that took like apical cellular protrusions appearing between days 20 and 21 of the natural menstrual cycle. There are many factors that regulate the changes typical of the implantation window and the appearance of the pinopodes. The embryonic and maternal expression of growth factors and cytokines, calcitonin, HOX genes and cell adhesion molecules might all play a major role in the phenomenon of implantation. The cytokines function as chemical messengers and can serve as biomarkers of uterine receptivity. Understanding the function of these biomarkers and their role in determining the implantation window in women, will help us to diagnose and treat infertile couples more efficiently. (C) 2003 Published by Elsevier Ltd.