Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
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DOI：
10.1016/j.lfs.2005.09.007
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发表时间：
2005-12-22
期刊：
影响因子：
6.1
通讯作者：
Hamann MT
中科院分区：
文献类型：
--
作者：
Gul W;Hamann MT
海洋环境产生来自各种结构类别的天然产物，这些天然产物对许多疾病靶标表现出活性。从历史上看，海洋天然产品主要是作为抗癌剂开发的。吲哚类生物碱是一类具有独特开发前景的海洋天然产物。本文综述了海洋来源的吲哚生物碱的文献，并重点介绍了我们自己的研究。吲哚生物碱的生物活性包括：细胞毒性、抗病毒、抗寄生虫、抗炎、5-羟色胺拮抗、钙释放、钙调素拮抗等。
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities.