Dynamic Nuclear Structure Emerges from Chromatin Cross-Links and Motors
Dynamic Nuclear Structure Emerges from Chromatin Cross-Links and Motors
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DOI：
10.1103/physrevlett.126.158101
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发表时间：
2021-04-14
影响因子：
8.6
通讯作者：
Schwarz, J. M.
中科院分区：
文献类型：
--
作者：
Liu, Kuang;Patteson, Alison E.;Schwarz, J. M.
细胞核内有染色体，染色体与核纤层蛋白丝的软壳相连。实验表明，相关的染色体动力学和核形状波动来自运动活动。为了确定的物理机制，我们开发了一个活跃的，交联的劳斯链绑定到一个聚合物壳模型。系统大小的相关运动发生，但需要运动活动和交叉链接。特别是收缩马达，通过驱动异常的密度波动来增强染色体动力学。核形状的波动取决于电机的强度，交联，和染色体的结合。因此，复杂的染色体动力学和核形状出现从一个最小的，活跃的染色体-纤层系统。
The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin protein filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, cross-linked Rouse chain bound to a polymeric shell. System-sized correlated motions occur but require both motor activity and cross-links. Contractile motors, in particular, enhance chromosome dynamics by driving anomalous density fluctuations. Nuclear shape fluctuations depend on motor strength, cross-linking, and chromosomelamina binding. Therefore, complex chromosome dynamics and nuclear shape emerge from a minimal, active chromosome-lamina system.