Control of motor axon guidance in the zebrafish embryo
Control of motor axon guidance in the zebrafish embryo
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DOI：
10.1016/s0361-9230(00)00382-8
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发表时间：
2000-11-15
影响因子：
3.8
通讯作者：
Beattie, CE
中科院分区：
文献类型：
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作者：
Beattie, CE
近二十年来，斑马鱼神经肌肉系统一直是研究运动轴突引导的典范模型。特别是，表征和详细的分析集中在早期发育的初级运动神经元的发育和轴突发生，在发育的第一天，神经肌肉连接仅限于三个初级运动神经元，每个脊髓半节支配三个离散的肌节领土。在活的胚胎中观察染料标记的初级运动轴突显示，轴突发生是高度定型的，每个初级运动轴突沿着沿着特定的通路延伸并显示特定的特征。利用斑马鱼的独特属性，特别是分析活胚胎中运动神经元的能力和诱导突变的能力，已经允许全面的细胞，分子和遗传方法来识别控制神经肌肉连接形成的机制，从这一工作中获得的知识不仅涉及斑马鱼，而且涉及一般的脊椎动物轴突指导。(C)2001 Elsevier Science Inc.
The zebrafish neuromuscular system has been an exemplary model for studying motor axon guidance since its detailed characterization almost two decades ago. In particular, characterization and detailed analysis has focused on the development and axogenesis of early developing primary motoneurons, During the first day of development, neuromuscular connections are limited to three primary motoneurons per spinal cord hemisegment innervating three discreet myotome territories. Observations of dye labeled primary motor axons in living embryos revealed that axogenesis is highly stereotyped with each primary motor axon extending along specific pathways and displaying particular characteristics. Exploiting the unique attributes of zebrafish, notably the ability to analyze motoneurons in living embryos and the capability to induce mutations, has allowed a comprehensive cellular, molecular and genetic approach to discerning the mechanisms that control the formation of neuromuscular connectivity, Knowledge gained from this body of work not only relates to zebrafish, but to vertebrate axon guidance in general. (C) 2001 Elsevier Science Inc.