DElevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis
DElevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis
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DOI：
10.1016/j.joca.2006.10.010
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发表时间：
2007-05-01
影响因子：
7
通讯作者：
Crow, M. K.
中科院分区：
文献类型：
--
作者：
Pearle, A. D.;Scanzello, C. R.;Crow, M. K.
目标：C-反应蛋白（CRP）与骨关节炎（OA）患者的疾病进展相关，但其原因尚不清楚。我们假设，较高的CRP将与当地的炎症反应的结果在关节的OA患者。方法：血浆和滑膜标本从54 OA患者接受全髋关节或膝关节置换术或关节镜检查。从其中25例患者中获得滑液。对苏木素和伊红染色的滑膜切片进行炎症细胞浸润程度评分。血浆高敏C反应蛋白（hsCRP）水平，血清和滑液白细胞介素（IL）-6和IL-1 β水平测定酶联免疫吸附试验。结果：57%的特发性OA患者的滑膜内炎性浸润。炎症浸润患者的平均hsCRP水平显著高于无炎症患者（4.7 +/- 5.0 mg/L vs 1.7 +/- 3.6 mg/L，P = 0.003）。hsCRP水平与滑膜液IL-6（r = 0.64，P = 0.0006）、滑膜炎性浸润程度（r = 0.43，P = 0.002）和体重指数（r = 0.31，P = 0.02）显著相关。多因素分析显示，炎症浸润程度与hsCRP水平显著相关（P = 0.026）。结论：hsCRP水平反映了OA患者滑膜炎症的程度，可能与滑膜IL-6的产生有关。未来的研究需要澄清这些浸润和他们的产品可能有助于疾病的发病机制。(C)2006年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: C-reactive protein (CRP) has been associated with disease progression in patients with osteoarthritis (OA), but the reasons for this remain unclear. We hypothesized that higher CRP would be related to local inflammatory findings in the joints of patients with OA.Methods: Plasma and synovial membrane specimens from 54 OA patients undergoing total hip or knee arthroplasty or arthroscopy were obtained. Synovial fluid was obtained from 25 of these patients. Hematoxylin and eosin stained synovial membrane sections were scored for degree of inflammatory cell infiltration. Plasma high-sensitivity CRP (hsCRP) levels, and serum and synovial fluid interleukin (IL)-6 and IL-1 beta levels were measured by enzyme-linked immunosorbent assay.Results: Fifty-seven percent of patients with idiopathic OA had inflammatory infiltrates within the synovial membrane. The mean hsCRP level in patients with inflammatory infiltrates was significantly higher than those without inflammation (4.7 +/- 5.0 mg/L vs 1.7 +/- 3.6 mg/L, P = 0.003). There were significant correlations between hsCRP levels and synovial fluid IL-6 (r = 0.64, P = 0.0006), degree of synovial inflammatory infiltration (r = 0.43, P = 0.002), and body mass index (r = 0.31, P = 0.02). Multivariate analysis indicated that only degree of inflammatory infiltrate was significantly associated with hsCRP level (P = 0.026).Conclusion: These results suggest that systemic hsCRP levels reflect synovial inflammation in OA patients, perhaps by means of synovial IL-6 production. Future studies are needed to clarify how these infiltrates and their products may contribute to disease pathogenesis. (C) 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.