Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultrasonic vocalizations in rats
Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultrasonic vocalizations in rats
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DOI：
10.1037/0735-7044.115.4.940
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发表时间：
2001-08-01
影响因子：
1.9
通讯作者：
Ikemoto, S
中科院分区：
文献类型：
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作者：
Burgdorf, J;Knutson, B;Ikemoto, S
作者假设，在成年大鼠中，50千赫的超声波发声（usv）反映了一种以高唤醒和期望奖励为特征的状态。本研究通过检测NAcc -安非他明（AMPH）微注射对usv的影响，探讨伏隔核（NAcc）的多巴胺激动作用（dopamine agonism）是否能引起这种食欲状态。nacc内AMPH注射（单方面0.3、1.0、3.0、10.0马克杯）产生了50 khz usv的强劲剂量依赖性增加，这不能通过伴随的运动活动增加（LA）来解释。然而，将AMPH注射到背侧控制尾状壳核部位会产生适度的剂量依赖性的LA增加，而不会显著增加50 khz usv。这些发现表明，NAcc AMPH显微注射选择性地唤起大鼠50 khz的usv，支持了NAcc多巴胺升高可能无条件地引发奖励预期状态的观点。
The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 mug unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation.