Bmc Medical Genetics Association between Promoter -1607 Polymorphism of Mmp1 and Lumbar Disc Disease in Southern Chinese

Bmc Medical Genetics Association between Promoter -1607 Polymorphism of Mmp1 and Lumbar Disc Disease in Southern Chinese
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通讯作者：
You-Qiang Song;Daniel Wh;Ho;J. Karppinen;Patrick Y P Kao;B. Fan;K. Luk;S. Yip;J. C. Leong-
You-Qiang Song;Daniel Wh;Ho;J. Karppinen;Patrick Y P Kao;B. Fan;K. Luk;S. Yip;J. C. Leong-
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作者：
You-Qiang Song;Daniel Wh;Ho;J. Karppinen;Patrick Y P Kao;B. Fan;K. Luk;S. Yip;J. C. Leong-

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背景：基质金属蛋白酶(MMPs)参与了椎间盘细胞外基质的降解。MMP1基因的鸟氨酸插入/缺失(G/D)单核苷酸多态(-1607启动子多态)显著影响启动子活性和相应的转录水平。因此，它是DDD遗传学研究的一个很好的候选基因。
Background: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc. A SNP for guanine insertion/deletion (G/D), the-1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level. Hence it is a good candidate for genetic studies in DDD.