[Roles of cytokines and growth factors in atherogenesis].
[Roles of cytokines and growth factors in atherogenesis].
复制标题
[细胞因子和生长因子在动脉粥样硬化形成中的作用]。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Kuroki
中科院分区：
文献类型：
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作者：
M. Kawakami;M. Kuroki
在动脉粥样硬化病变中，通常在正常动脉中不表达的各种细胞因子和生长因子上调。它们中的一些包括PDGF、bFGF、HB-EGF、IGF-1、IL-1和TGF-β以及TNF通过刺激血管平滑肌细胞的趋化性和增殖以及这些细胞产生细胞外基质物质如蛋白聚糖、胶原和弹性纤维而在动脉粥样硬化形成中起关键作用。内皮细胞和巨噬细胞也是这些细胞因子和生长因子的靶细胞和来源。这些细胞因子或生长因子的产生受到彼此分子或自身分子的调节，形成复杂的细胞因子网络。了解和控制这些细胞因子在血管壁中的作用将有助于深入了解动脉粥样硬化的发生机制，并有助于开发更好的预防方法。
In lesions of atherosclerosis, various cytokines and growth factors, which are generally not expressed in the normal artery, are upregulated. Several of them including PDGF, bFGF, HB-EGF, IGF-1, IL-1 and TGF-beta and TNF play key roles in atherogenesis by stimulating chemotaxis and proliferation of vascular smooth muscle cells and production of extracellular matrix substances such as proteoglycans, collagen and elastic fibers by those cells. Endothelial cells and macrophages are also the targets as well as the sources of those cytokines and growth factors. The production of those cytokines or growth factors are regulated by molecules of each other or by themselves forming a complex cytokine network. Understanding and control of the roles of those cytokines in vascular walls will provide an insight on the mechanism of atherogenesis and contribute to the development of better ways to its prevention.