Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex
Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex
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DOI：
10.1016/s0896-6273(00)00008-8
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发表时间：
2000-07-01
期刊：
影响因子：
16.2
通讯作者：
Feldman, DE
中科院分区：
文献类型：
--
作者：
Feldman, DE
躯体感觉（S1）和视觉（V1）皮层的经验依赖性可塑性涉及对剥夺的感觉输入（闭上眼睛或修剪胡须）的反应的快速抑制。这种抑郁症首先发生在层II/III，并可能反映在垂直输入从IV层到层II/III金字塔的可塑性。在这里，我描述了一个基于时间的，联想形式的长时程增强和抑郁症（LTP/LTD）在这个突触在S1。当兴奋性突触后电位（EPSP）在一个狭窄的时间窗口内导致单个突触后动作电位（AP）时，LTP发生，当AP在一个明显更宽的窗口内导致EPSP时，LTD发生。这个长的LTD窗口在基于时间的学习规则中是不寻常的，它会导致与突触后AP不相关的EPSP变得抑郁。这种行为表明了一个简单的模型，在S1和V1的剥夺感觉反应的抑郁症。
Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I describe a timing-based, associative form of long-term potentiation and depression (LTP/LTD) at this synapse in S1. LTP occurred when excitatory postsynaptic potentials (EPSPs) led single postsynaptic action potentials (APs) within a narrow temporal window, and LTD occurred when APs led EPSPs within a significantly broader window. This long LTD window is unusual among timing-based learning rules and causes EPSPs that are uncorrelated with postsynaptic APs to become depressed. This behavior suggests a simple model for depression of deprived sensory responses in S1 and V1.