Target influence on aging of myelinated sensory nerve fibres
Target influence on aging of myelinated sensory nerve fibres
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DOI：
10.1016/0197-4580(95)02021-7
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发表时间：
1996-02
影响因子：
4.2
通讯作者：
Carina S. Johansson;M. Stenström;C. Hildebrand
中科院分区：
文献类型：
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作者：
Carina S. Johansson;M. Stenström;C. Hildebrand
大鼠下肺泡神经（IAN）中的大髓鞘纤维表现出与年龄相关的畸变，部分类似于靶剥夺神经的改变。在进入下颌管后不久，大鼠IAN分裂为精神（MN）和下牙（IDN）部分。这提供了一种比较年龄相关畸变发生的可能性——在MN和IDN中，它们投射到不同的目标类型。因此，我们研究了不同年龄成年大鼠MNs和IDNs的戏弄纤维制剂中结间长度(L)和纤维直径(D)的关系。结果表明，6 ~ 24月龄大鼠MNs与IDNs的L/D关系相似，但IDNs的不规则性明显高于26 ~ 30月龄大鼠MNs。这种差异可能与以下事实有关：在2岁以上的大鼠中，idn神经支配的下颌牙列正在退化，而MN的皮肤粘膜靶点则没有退化。我们认为，靶标恶化可能是大髓鞘周围神经纤维结构畸变发生率增加的一个主要因素。
Large myelinated fibres in the rat inferior alveolar nerve (IAN) exhibit age-related aberrations partly similar to alterations in target-deprived nerves. Shortly after entering the mandibular canal the rat IAN splits into a mental (MN) and an inferior dental (IDN) portion. This offers a possibility to compare the occurrence of age-related aberrations-in the MN and the IDN, which project to different target types. Hence, we examined the relation between internodal length (L) and fibre diameter (D) in teased fibre preparations of MNs and IDNs from adult rats of different ages. The results show that the relation L/D is similar in MNs and IDNs of 6- to 24-month-old rats and that it is significantly more irregular in IDNs than in MNs of 26- to 30-month-old rats. This difference may be related to the fact that the IDN-innervated mandibular dentition is deteriorating in rats older than 2 years, whereas the muco-cutaneous target of the MN is not. We suggest that target deterioration may be one major factor behind the increasing incidence of structural aberrations in large myelinated peripheral nerve fibres.