Catalyst-Free Plasma-Assisted Copolymerization of Poly(ε-caprolactone)-poly(ethylene glycol) for Biomedical Applications
Catalyst-Free Plasma-Assisted Copolymerization of Poly(ε-caprolactone)-poly(ethylene glycol) for Biomedical Applications
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DOI：
10.1021/mz300188s
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发表时间：
2012-06-01
影响因子：
7.015
通讯作者：
Arefi-Khonsari, Farzaneh
中科院分区：
文献类型：
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作者：
Bhatt, Sudhir;Pulpytel, Jerome;Arefi-Khonsari, Farzaneh
无催化剂开环聚合（ROP）策略的开发是为了克服多步湿化学过程中催化剂去除不完全且昂贵的缺点。通过一步、低压、脉冲等离子体聚合工艺沉积纳米尺寸的生物相容性和低分子量聚（ε-carolactone）-聚（乙二醇）（PCL-PEG）共聚物涂层。在不同的单体进料比和有效等离子体功率下进行实验。通过 XPS 以及 MALDI ToF 分析涂层。椭圆光度测量显示沉积速率范围为 1.3 至 3 nm/min，具体取决于反应器中引入的 PCL/PEG 前体的比例。我们的结果表明，等离子体共聚 PCL-PEG 涂层可以以细胞粘附的方式定制，方便用于生物医学植入物，如人造皮肤基底，或细胞排斥剂，可用作导尿管、心脏支架等的抗生物污染表面。这项研究的总体目标是通过在脉冲等离子体环境中将 PCL 与 PEG 共聚来定制 PCL 的表面特性，以提高其在组织工程和生物医学科学中的适用性。
Catalyst-free ring-opening polymerization (ROP) strategy was developed to overcome the disadvantage of incomplete and expensive removal of catalyst used during the multistep wet chemical processes. Nano-sized biocompatible and low molecular weight poly(epsilon-carolactone)-poly(ethylene glycol) (PCL-PEG) copolymer coatings were deposited via a single-step, low-pressure, pulsed-plasma polymerization process. Experiments were performed at different monomer feed ratio and effective plasma power. The coatings were analyzed by XPS, as well as MALDI ToF. Ellipsometric measurement showed deposition rates ranging from 1.3 to 3 nm/min, depending on the ratio of the PCL/PEG precursors introduced in the reactor. Our results have demonstrated that plasma copolymerized PCL-PEG coatings can be tailored in such a way to be cell adherent, convenient for biomedical implants such as artificial skin substrates, or cell repellent, which can be used as antibiofouling surfaces for urethral catheters, cardiac stents, and so on. The global objective of this study is to tailor the surface properties of PCL by copolymerizing it with PEG in the pulsed plasma environment to improve their applicability in tissue engineering and biomedical science.